Didn't have a chance to write up a detailed post, either on a fruit or the topic I was originally thinking about. I think they're neat and they taste good.
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You could use the airlock technique. That's what I use with my luer-slip syringes (and other people I know also use that technique). Once you've drawn your desired amount of E, withdraw it from the vial, point the needle up, pull the plunger to draw around 0,2 mL of air in, switch needles now if you want to use a different needle for injecting, and now point the needle downwards and let the air accumulate as a single bubble at the top with the plunger. It is now ready to inject. Inject the E together with the air (E first, then the air). What happens is that once all E has been injected, the air in the syringe will push all the E that's stuck in deadspace out, so the loss from deadspace is reduced.
Before you panic with the idea of injecting air, know that small amounts of air like the one mentioned are perfectly fine to be injected SQ or IM (I think you can theoretically also inject a whole mL and be fine). But absolutely do not inject any bubbles when administering substances intravenously though.
Note that you may want to adjust your dose now, as you will now be injecting more E than you did before.
Your body can absorb a certain amount of air but the bigger problem with it is it usually hurts more for not much benefit. Technically you're giving yourself subcutaneous emphysema but it's really not a big deal if its a couple mls and you only inject once a week or whatever. The amount you "lose" in the needle is negligible, just think of how tiny the volume is with that gauge of a needle times it's length - it's essentially nothing. A 27 g needle is like a fifth of a mm for its inner diameter. The benefit of squeezing out that little bit of E vs the risk of harm and the actual pain it'll likely cause is just not worth it. But if that's your practice and it works for you and you don't mind the pain, go for it.
You can technically inject a small amount of bubble IV cause your body will absorb a tiny embolism like that - but at work, if I do a couple bubbles, someone else does, som other people do - it adds up. I stick with a no bubble tolerance for IV and IM injections as well.
I didn't know the air lock thing had a name but that's how I do it at work and for myself! Except I clear the syringe of air after switching needles lol.
(it refers to the act of injecting air after the substance, not the act of clearing deadspace when switching needles)
I think it is called airlocking because one of its uses is to prevent the liquid from escaping through the tunnel made by the syringe, but I don't really see a difference in leakage (perhaps it's an IM thing) and just mainly use it because I like the idea of avoiding loss from deadspace.
I may be mistaken, but isn't most deadspace not from the metallic part of the needle?
With the syringes I use, according to the diagram, a third of the E drawn would be lost to deadspace with 0,1 mL injections. That to me sounds like a significant fraction.