Theres a few hormones we think are the main regulators of sleep. Melatonin (its endogenous, not just a thing you pick up at the store), adenosine, seratonin and cortisol.

Cortisol will spike at 0200H for more or less everyone, so if youre not asleep its gonna contribute to the tired but wired feeling of being awake. Its at its lowest, in a regular sleep cycle, at around midnight.

Melatonin just gets produced more and more in darkness, the longer the darkness the more melatonin builds up. It tells you youre tired and helps you actually fall asleep. If you keep blue lights on or theres bright lights, you wont produce as much melatonin.

Adenosine isnt like a primary sleep hormone but the longer youre awake the more it build up, the sleepier you feel. If you drink caffeine, its an adenosine receptor blocker, which is why people feel awake with it. But caffeine can have quite a long half life and still be cycling around if you have one at 3 PM and youre trying to sleep at 10 PM say.

Serotonin, not a primary sleep hormone but it does get used to produce melatonin. Cycling serum seratonin makes you feel awake, happy, alert. Through the day itll start getting converted to melatonin, which makes you feel ssleepy. If your seratonin activity is messed up, itll mess up your melatonin. So if someone had depression, anxiety disorder, even some clinical disordered eating - it can all fuck with your sleep on a hormonal level. Which is terrible because poor sleep can make mood worse, and good sleep can make mood vastly, VASTLY improve.

So if she's awake every day at 0540H, its cause all these hormones are in a cycle and shes helped set it presumably after a good long while using that alarm.

People always say theyd simply kill bad people if they had an irl death note (kinda ignoring the point of the manga or show lol). Some people think they'd be clever and choose to kill no one, but Ryuk will kill the owner if he finds them too boring... it really is better to simply ignore the death note at all costs. And if you accidentally pick it up, find some way of being entertaining I guess.

Well, youre under a lot of stress and sleep deprivation. It tracks you might have a bare nerve

Whats the failure though...? You got a least one undergrad and now are about to get a masters

Since one of you could be driving or minding the other, its probably better if you didnt have it at the same time

Its weird to explain, its "cleaner"? They probably clean their lines much better in Dublin proper and obviously at St James Gate. It is much creamier and softer too. Who knows how much the local river impacts taste too - plus it doesnt sit in cans or kegs for long. Outside of Dublin, it did taste the same in Ireland as anywhere else in the world. And rhe actual brewery proper was another tier above that too.

I like Guinness, but its all basically the same outside Dublin and outside St James Gate especially to me. Not quite as good, I did have some NA stuff once to cook with! I think the etoh might help do something in the recipes but... the taste wasnt far off either.

Jesus was the first vampire and the lance of longinus piercing him created the second generation of vampires 🧛‍♀️

Paramore 🤘

Like a sim????

Honey, you HAVE to sleep better. Like more than pretty much anything else in your life considering how dire youve described it

Cypro is the traditional treatment for prostate cancer, but there are forms that are resistant to T blockers. Only ones I saw were when it was very well developed and grown quite a bit not like something you randomly pick up. Prostate cancer is T driven so if youre on blockers or you had an orchie, the chances of developing it should more or less be zero I suppose. If you had some cancer brewing and it wasnt resistant to T deprivation... well if you take HRT or get an orchie you already were doing the standard treatment. I suppose its possible for someone who had it in full bloom to transition past when deprivation would be useful? But that seems very very niche and presumably youd have been screened once pre anything (pre egg crack probably).