chapotraphouse

Between the genocide and the Cheney's. Absolutely disgusted and saddened by this world lately.

Yes I'm glad Kamala ate shit in this election, the Democrats deserve to lose forever. I am starting to lose remaining respect for people irl who still support them and it pains me because people I love have abstracted and dismissed a genocide as an "election issue".

SAN DIEGO--(BUSINESS WIRE)--Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a commercial messenger RNA medicines company focused on the development of infectious disease vaccines and opportunities within liver and respiratory rare diseases, today announced that the U.S. Food and Drug Administration (FDA) has issued a “Study Can Proceed” notification for the Company’s Investigational New Drug (IND) application, ARCT-2304, a self-amplifying mRNA (sa-mRNA) vaccine candidate for active immunization to prevent pandemic influenza disease caused by H5N1 virus. The clinical study is funded by Biomedical Advanced Research and Development Authority (BARDA) and designed to enroll approximately 200 healthy adults in the United States.

The Phase 1 clinical trial is designed to evaluate the safety, reactogenicity, and immunogenicity of ARCT-2304 as a potential vaccine to protect against the highly pathogenic H5N1 avian influenza.

"Arcturus is actively engaged with the U.S. government to prepare for the next pandemic, and clearance to proceed into the clinic with our STARR® self-amplifying mRNA technology is a key step in this important process,” said Joseph Payne, President & CEO of Arcturus Therapeutics. “The Phase 1 clinical trial is designed to evaluate the safety, reactogenicity, and immunogenicity of ARCT-2304 as a potential vaccine to protect against the highly pathogenic H5N1 avian influenza.”

About ARCT-2304

ARCT-2304 is a sa-mRNA vaccine candidate formulated within a lipid nanoparticle (LNP). The sa-mRNA vaccine candidate is designed to make many copies of mRNA within the host cell after intramuscular injection to achieve enhanced expression of haemagglutinin (HA) and neuraminidase (NA) antigens, thereby enabling lower doses than conventional mRNA vaccines. Utilizing a mRNA-based platform for pandemic influenza vaccine development offers further options for meeting domestic vaccine manufacturing surge capacity goals. The technology may make vaccines available much sooner than egg- and cell-based technologies. The lyophilized vaccine formulation is stable in refrigerators, thereby simplifying cold-chain storage and reducing distribution risks.

The damage is done! Hundreds of thousands fell for this fucking kids analysis. This person spent a shit ton of time promoting Whitmer. No pushback from the Chapo Boys. Did they not know? Or just not care?

This MFer promoted Harris a fuck ton in terms of being electable and popular. We're better than this. What happened? Millennials wanted to be feel young by being around young folks? Or the lack of Matt letting this shit get out of hand? I really gotta know. I'm furious.

Now this scumbag is pretending they get to play both sides. Shit aint' right, but I see people embracing the lies. FUCK THIS.

I've seen so many pictures of him looking at him like he's a pest. I think it'd be funny if he gave him the finger and Elon would be sooooo butthurt.

I made a substack for this so you can send it to your libbed up friends and family. Also like/comment on the article that would be cool, im sure that helps spread it somehow

Premise: A lot of great socialist and left-leaning people have dismantled the main point of the Bidenomics argument by showing that many millions of people were left behind. This article is coming in to destroy what little remains after that - even the best case scenario is still just wrong and delusional.

In southern Gaza, people are living in indescribable suffering. Hunger threatens the lives of children and families, amid a severe shortage of food and resources. Every passing day intensifies the tragedy, leaving them facing death from hunger. They are in urgent need of support before it’s too late. https://gofund.me/1222af19

Republicans are projected to keep control of the House of Representatives, handing the party total control of Washington with former President Trump back in the White House in January.

Decision Desk HQ projected the GOP would hold the House by winning its 218th seat on Monday, the number needed for a majority in the lower chamber.

https://en.wikipedia.org/wiki/Kecksburg,_Pennsylvania

Like the Republicans lean too heavily into enforcing their Christian culture war bullshit, ban GTAVI and obscenity and alienate the porn and video game-loving young dude demographic. Also Trump blows up the economy and then dies, Vance becomes president and conservatives become the lame fuddy duddy nerds that everyone hates again

Alternatively, Gen Z men have all become NoFap wahhabists and welcome the bans

thank you for your service

In case you don't get it, that's Ella Emhoff and this post is making fun of that one post of Barron Trump after Trump lost in 2020.

Beria was a certified gem poster

the most embarrassing thing about this particular struggle session (no i will not read any of the posts) is the revelation that there's a large community filled with discord mods who are having what they consider to be Very Important discussions about the website all day

cross-posted from: https://lemmygrad.ml/post/432929

It may sound a little condescending, or like I’m bragging about something as elementary as putting on my pants or brushing my teeth, but I wouldn’t say that this thread is entirely unjustified either considering how so many adults are (almost) clueless about the subject.

It took me only 0.5–1 hour(s) to master this, and any frustration that I had was minor.

(If you are experiencing graphical glitches like giant text boxes, see here for advice.)

Russia wants Trump to win, right? Well, Trump only won because of Joe Biden doing nothing for 4 years, then staying in the race despite being clearly too demented to be competent right up until it was too late- these actions DIRECTLY resulted in TRUMP'S ELECTION.

JUST LIKE PUTIN WOULD HAVE WANTED

If people don't stop being so inflamed about this newest drama I, Moo Deng, will become a most vicious killer.

Chill......or else ima chomp ya.

cross-posted from: https://lemmygrad.ml/post/6210802

Stolen from Comrade Sisko

https://www.reddit.com/r/Hasan_Piker/comments/1gomthb/nick_fuentes_maces_57_year_old_woman_who_showed/

White nationalist Nick Fuentes was doxed on Friday in the fallout of his viral “My body, your choice” comment. Today, a 57 year old Jewish female journalist showed up to his house, rang the doorbell, and was maced and shoved by Fuentes. Cops and an ambulance showed up. Linked is her Facebook post. Details are limited because this is breaking.

https://facebook.com/story.php?story_fbid=10161831224895688&id=578640687

cross-posted from: https://lemmygrad.ml/post/6209627

I just set up miniflux now I need RSS feeds. Please give.