this post was submitted on 31 Mar 2025
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traaaaaaannnnnnnnnns

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Warning: Grapefruit can interact with drugs, such as decreasing the effectiveness of estradiol, making Oxycodone last longer, increasing blood levels when on Viagra, and much more.

Grapefruit inhibits multiple enzymes in the small intestine, most notably CYP3A4. CYP3A4 is involved in the breaking down of a lot of drugs, so when it's inhibited Oxycodone becomes inactive slower, and estradiol won't break down all the way into estrogen. Drugs that are affected by grapefruit will often have warnings on their packaging

Personally, I like putting just a little bit of salt on my grapefruit, to counteract the bitter flavor. Dumping sugar on it doesn't help. Grapefruits are about half as sour as lemons, since they have half the citric acid content.

Grapefruits were accidentally created as a cross between the sweet orange and the pomelo, in Barbados. Those fruits originate from Asia, but were brought to the Caribbean in the 17th century. Since it's parent fruits are native to Asia, it grows well in Asia too.

some-controversy and peekaboo (China and Vietnam) are the two largest producers of Grapefruits, producing collectively 6.3 million tons out of the 9.8 million tons of worldwide production.

The painting was made by Robert Papp, who has a website here: https://robertpapp.com/. I don't really know anything about the guy.

The lemon things with all of the recipes was really cool, but to be honest I just like grapefruit raw, cut in half and ate with a spoon.


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[โ€“] [email protected] 11 points 2 weeks ago (8 children)

me celebrating my loosely reconstructed ancient ass roman pagan ritual with nobody wondering how many other people on earth are celebrating today and if the both of us would meet up at some point

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[โ€“] [email protected] 11 points 2 weeks ago

Woke up this mornin', got some gabagool

tony-cheer

[โ€“] [email protected] 10 points 2 weeks ago (2 children)

ADHD medsVyvanse seems good so far. Thats the update. I can do my job now and focus on what I want to. Its easy. Let's hope it lasts

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[โ€“] [email protected] 10 points 2 weeks ago (4 children)

Thank you to everyone who liked the previous mega, I hope I inspired you to make a lemon treat

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[โ€“] [email protected] 10 points 2 weeks ago (1 children)

all capsI FUCKING LOVE GARAPEFRUIT lets-fucking-go

did not know it interfered with estrogen though that's sad. even with injections?

[โ€“] [email protected] 10 points 2 weeks ago (3 children)

Estradiol regardless of form gets metabolized by a specific liver enzyme. Some specific part of grapefruit, for reasons known only to god, interferes with that enzyme. So it will mess with your levels. If you have a grapefruit every once in a while, like once a month or less, youll probably be fine.

CBD also interferes with that liver enzyme but since most people stick with whatever their regiment of weed intake before and after HRT, it's kind of baked in - but technically we should be advising no CBD and likely no cannabis in general, but imagine that struggle yeesh. Grapefruit, on the other hand, people don't eat it on the regular and some meds go through the same liver enzyme pathway. So generally, if you are taking any med that is affected by grapefruit you should just skip the grapefruit.

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[โ€“] [email protected] 10 points 1 week ago (1 children)

CW Social DysphoriaFeeling incredibly dysphoric and isolated from the women in my life, today.

I feel like my transition has stagnated for a variety of reasons and I wish I could reach out to some of the cis girls in my life for advice on feminine things, but it's hard because I don't know what I don't know. And if I want to like, engage with them about "girl stuff", and don't even know where to start.

And I can't just be like "hi please talk to me about girl things" cuz then I'm the weirdo who doesn't even know what things to talk about.

And then I try to express this frustration to them, and I don't know if it really registers...

Like...idk! Just talk to me! Help me! Help me feel valued and included, rather then just a weird, annoying, pantomime of femininity!

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[โ€“] [email protected] 10 points 1 week ago (3 children)

i-think-that if a game lets me adjust my facial hair I should also be able to adjust my boob size

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[โ€“] [email protected] 10 points 2 weeks ago (2 children)

please suggest me games like genshin and botw which have good exploration and puzzling

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[โ€“] [email protected] 10 points 2 weeks ago

havin' a case of the Gloom today

It's cold and dark and rainy and miserable here and I'm exhausted and sad and don't feel good so I'm just gonna go to bed early and write off the whole day catgirl-flop

[โ€“] [email protected] 10 points 2 weeks ago (1 children)

depresso-posting

I wish "getting better" didn't have to hurt so much. I know rationally that having a decent amount of neutral days, and even very occasionally having a good day, is better than just feeling continuously like the lowest shit day after day after day after day. But at least when I'm constantly broken down I can get kind of numb to it, right now it's like I feel good just enough to not get used to feeling bad, just enough to be constantly hit with this soulcrushing whiplash. Built up just enough that I can break again.

I know it's all part of the process, like building a muscle, it gets torn and heals back stronger bit by bit by bit over time. Just wish that that could get from the part of my brain that knows things to the part of my brain that feels things, just wish that in the meantime I wasn't just some whiny little shit who feels bad about having good days, like what the fuck.

[โ€“] [email protected] 10 points 2 weeks ago

spoilerYea the whole "trending upward" thing still kinda sucks and I think is where I'm at.

[โ€“] [email protected] 10 points 1 week ago

They made an emoji of me ๐Ÿซฉ

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