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Question about HRT for my girlfriend (hexbear.net)
submitted 1 week ago by [M] to c/traaaaaaannnnnnnnnns@hexbear.net
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Hello! As some of y'all may know, I locked down a trans MILF baddie about a year ago (actually 11 months as of yesterday!). She's 12 years older than me and like twice my size, I live for this shit.

Well anyways, she's been on hormones for 2 years. She's been taking low doses considering how long she's been on it because she is bipolar (y'all know I haven't dated someone without a cluster b personality disorder since Chapo was still on Reddit) and taking anything more than what she's taking will make her dangerously manic. So yeah, none of that.

Her appointment was a couple days ago. Got her blood drawn, and we're both confused by the numbers. So she's at 88 estrogen, which is below the 100 they look for typically but is close enough really. However, her testosterone was even higher than when she started HRT, around 160.

I'm still waiting for her to text me doses, but she's on Estrodial, Progesterone and Spiro, all oral, no needles or sublingual. Losartan for blood pressure. And CBN at night (with her progesterone dose, mentioning that because I know the two have interactions).

She's calling her nurse practitioner tomorrow, but I figured I'd ask a bunch of trans people what they think of it

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[โ€“] 12 points 1 week ago* (last edited 1 week ago) (9 children)

Progesterone (oral, suppository, or otherwise) has a documented effect specifically during Tanner Stages III and IV, but outside of this specific developmental stage of a handful of months, you're definitely right about it having dubious impact.

Spironolactone is a prodrug but its active metabolites are actually steroidogenesis inhibitors, which is very specifically relevant for patients with Bipolar.

Cyproterone is a really good pick for an antiandrogen, but may be harder to acquire for some people who aren't as able to DIY since it doesn't have FDA approval.

Injection of estradiol is great for most people because it avoids first-pass metabolism, but it's extremely not recommended for patients with Bipolar disorder because it has higher fluctuations in serum levels with dramatic peaking right after the injection which can induce a manic episode. This is actually how healthcare practitioners first discovered that estradiol can induce mania.

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  • [โ€“] [S] 7 points 1 week ago

    Oh God, this is such a manic comment. Normally I delete posts like this when I write them, but honestly I kinda want someone to see what my mania looks like writing wise. It's uh, very interesting I guess is a way to write it. IDK , some of my people think it's amazing others know exactly what it is and hate it. The lesson here is that I could have been the new Jim Jones if I wanted to. The better you know me, the know you know how true that is, I didn't come up with that comparison myself it was my old drug abuse councilor

    Well, she's dating me. Sourcing cypro isn't the problem, I can still get literally any drug I want (recreational or otherwise) right now and I know this to be true. I've had dealer's choice of everything for years, even after I sobered the fuck up. There's nothing stopping me from purchasing any drug you can think of that's available in America. I provided my Mom her bougie ass birth control she gets only because she's married to a vice president in one of America's biggest companies. I'm able to get shit that even rich insurance companies in America can't get for their patients.

    If I think I can convince her to try it, I'll source it and that's no big deal. But that's all contingent on getting her to actually try it and see what she thinks, if I can't get her willing to try it ordering it in will do no good. And uh, I'll just say it isn't easy to convince her to take anything that isn't prescribed by a doctor. She won't even take Ibuprofen when I offer it sometimes, we're not talking about normal drug avoidance I mean she won't even take basic OTC stuff. I'll be like "Gurl you've had a headache for 2 weeks straight" and she'll be like "Yeah but Advil (I actually only carry Naproxen, its always actual Advil) will make my tummy hurt :(" and then I have to fight the hood pharmacist inside of Leyla from just dropping an Advil in her mouth when she sleeps. Idk, I used to literally drug people with kratom to get them through withdrawal from fentanyl, I don't regret anything I did back then because every one of those people is still alive, but I've definitely done some morally questionable shit in this area for the right reason

    Idk, maybe some of y'all don't remember but it was about 2 years ago I was posting on here asking about advice for providing people DIY HRT. I was creating sublingual Estrodial drops for monotherapy for people around me up until I went to rehab. I'd pay rent, people's med shipments, then spend the rest on alcohol to keep from withdrawals. I was also shipping in extras of everybody's meds because there was some fuckery going on with insurance at the time. I don't fully remember the context, but even my mom with bougie insurance was expecting to lose it. There's a reason I have such a great reputation in my city despite spending a very long time in the city as a junkie.

    Sorry, I'm coming off my TCA/Main sleep med, I'm pretty manic and just shooting shit.i should have been asleep 4 hours ago but it just didn't work.

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  • [โ€“] [S] 5 points 1 week ago (2 children)

    Fuck, I'm manic and it's about to affect someone big so I might as well mention this. You might get a chuckle out of this. I have a call scheduled with Brown University for the withdrawal guides I wrote on here forever ago. Someone reached out to me off site and said they had some questions about my withdrawal guides FROM ON HERE, which honestly in my opinion now that some time has passed since writing them, functional but mid, I've done better.

    This is in 4 hours, I should have been sleeping this whole time but I lost access to many of the tools I use for sleep overnight. An ivy League University is literally interviewing me over posts I made on this site about 2 years ago, I feel like I'm getting fucking punked. Like huh, y'all couldn't have picked any other ex junkie that can tell people how to withdrawal from shit? I'm sure I'm not the only one writing shit like that, I'm not unique or special but for some fucking reason some people at Brown think I am.

    Oh well, at least it's Brown. Only Ivy League school I would have answered, I would have told any other one to fuck off. But yeah, fucking with my head that I'm doing an interview where this site is part of it in 4 hours. Like what the fuck? Maybe this is why my fellow bipolar people are all more brain fried than me. They're just constantly getting hit with mind melting shit like this, because ain't no way in hell some neurotypical does anything good enough for people to actually like them a few years later for their actions. If hell exists, it's all neurotypicals because they're like deathly allergic to integrity.

    Goddamn, amazing what manic rants sobriety gets me! I delete 80 percent of everything I type out on this website because I know it's usually just manic bullshit that doesn't matter, but you know what for once I'm going to make it everyone else's problem

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  • [โ€“] 2 points 1 week ago (1 child)

    meow-shark

    I liked reading it.

    โ“˜ This user is suspected of being a cat. Please report any suspicious behavior.

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  • [โ€“] [S] 2 points 1 week ago

    Thank you :) sometimes I get too long winded and lose my conciseness that makes me a good communicator when I'm manic, I don't know how good of a writer I am. Some days I think I'm really good and the people in my life say that I should start writing books and make a podcast.

    All my cis dude coworkers that I work with on my Tuesday shift say that I manage to be one of the funniest and wittiest people they've ever met. Like one time we were driving to the location in the work van. I told a joke that was just a throw away for me, I don't even remember it. But the driver of the car had to pull over on the highway because of how funny they all found this joke. I have the privilege of being able to go on autistic rants because I'm funny, I should do something with that

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  • [โ€“] 5 points 1 week ago* (3 children)

    dramatic peaking

    for valerate or enanthate/cypionate? Enanthate is a lot flatter I didn't know if that was still too spiky for some people.

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  • [โ€“] 5 points 1 week ago (2 children)

    All of the above. The relevant difference between these compounds is their half-life.

    Estradiol enanthate and estradiol cypionate last longer in the body but you're still adding a bunch of it into your body when you inject it, which will cause a spike in your levels.

    The spike will be slightly less dramatic than if you used estradiol valerate because there will be a larger quantity still remaining in the bloodstream, but it's the sudden increase in total quantity that causes the manic episode.

    Unfortunately a lot of practitioners just don't get this at all, and it seems like WPATH doesn't do a good job of identifying or communicating things like this. I've heard a lot of trans people describe WPATH as a gatekeeping org more than anything else, and I'd say that's consistent with how they handle (or rather, don't handle) the niche stuff like this.

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  • [โ€“] 4 points 1 week ago* (1 child)

    Okay cool, thank you. Just was looking at this and valerate, especially weekly like a lot of providers like to prescribe it, looks noticeably worse. enanthate doesn't look that sudden. But that does make sense, no matter how you slice it its a dose once a week compared to constantly like patches. But will try to remember for when I'm giving advice in the future.

    Yea wpath sucks for a lot of reasons.

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  • [โ€“] 4 points 1 week ago

    Yeah, don't get me wrong Valerate is much spikier. For most people enanthate is really smooth and consistent because of the long half life, but that comparatively teeny little spike is just too much variation on the brain side of the blood brain barrier for some folks.

    I feel like a lot of people don't even know that estradiol can cause manic episodes.

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