28
Question about HRT for my girlfriend (hexbear.net)
submitted 1 week ago by [M] to c/traaaaaaannnnnnnnnns@hexbear.net
22 comments fedilink hide all child comments
 

Hello! As some of y'all may know, I locked down a trans MILF baddie about a year ago (actually 11 months as of yesterday!). She's 12 years older than me and like twice my size, I live for this shit.

Well anyways, she's been on hormones for 2 years. She's been taking low doses considering how long she's been on it because she is bipolar (y'all know I haven't dated someone without a cluster b personality disorder since Chapo was still on Reddit) and taking anything more than what she's taking will make her dangerously manic. So yeah, none of that.

Her appointment was a couple days ago. Got her blood drawn, and we're both confused by the numbers. So she's at 88 estrogen, which is below the 100 they look for typically but is close enough really. However, her testosterone was even higher than when she started HRT, around 160.

I'm still waiting for her to text me doses, but she's on Estrodial, Progesterone and Spiro, all oral, no needles or sublingual. Losartan for blood pressure. And CBN at night (with her progesterone dose, mentioning that because I know the two have interactions).

She's calling her nurse practitioner tomorrow, but I figured I'd ask a bunch of trans people what they think of it

you are viewing a single comment's thread
view the rest of the comments
[–] 5 points 1 week ago* (3 children)

dramatic peaking

for valerate or enanthate/cypionate? Enanthate is a lot flatter I didn't know if that was still too spiky for some people.

  • permalink
  • fedilink
  • source
  • parent
  • hideshow 3 child comments
    •
  • [–] 5 points 1 week ago (2 children)

    All of the above. The relevant difference between these compounds is their half-life.

    Estradiol enanthate and estradiol cypionate last longer in the body but you're still adding a bunch of it into your body when you inject it, which will cause a spike in your levels.

    The spike will be slightly less dramatic than if you used estradiol valerate because there will be a larger quantity still remaining in the bloodstream, but it's the sudden increase in total quantity that causes the manic episode.

    Unfortunately a lot of practitioners just don't get this at all, and it seems like WPATH doesn't do a good job of identifying or communicating things like this. I've heard a lot of trans people describe WPATH as a gatekeeping org more than anything else, and I'd say that's consistent with how they handle (or rather, don't handle) the niche stuff like this.

  • permalink
  • fedilink
  • source
  • parent
  • hideshow 2 child comments
    •
  • [–] 4 points 1 week ago* (1 child)

    Okay cool, thank you. Just was looking at this and valerate, especially weekly like a lot of providers like to prescribe it, looks noticeably worse. enanthate doesn't look that sudden. But that does make sense, no matter how you slice it its a dose once a week compared to constantly like patches. But will try to remember for when I'm giving advice in the future.

    Yea wpath sucks for a lot of reasons.

  • permalink
  • fedilink
  • source
  • parent
  • hideshow 1 child comment
    •
  • [–] 4 points 1 week ago

    Yeah, don't get me wrong Valerate is much spikier. For most people enanthate is really smooth and consistent because of the long half life, but that comparatively teeny little spike is just too much variation on the brain side of the blood brain barrier for some folks.

    I feel like a lot of people don't even know that estradiol can cause manic episodes.

  • permalink
  • fedilink
  • source
  • parent