The 25th would never even get to Congress. Everyone in a position to invoke it is a Trump toady who wants him right where he is.

25th Amendment, Section 4

Whenever the Vice President and a majority of either the principal officers of the executive departments or of such other body as Congress may by law provide, transmit to the President pro tempore of the Senate and the Speaker of the House of Representatives their written declaration that the President is unable to discharge the powers and duties of his office, the Vice President shall immediately assume the powers and duties of the office as Acting President.

Trump has a better chance of being abducted by aliens.

The problem isn't that people don't know about the 25th, the problem is they don't know how it works.

Even if the cabinet invokes the 25th, the President can just say "nah, I'm cool" and that put's an end to the whole thing, unless congress votes to remove him at that time.

So it's actually harder than impeachment and removal. Either way, you're going to need lots of Republicans to remove him.