Play through the tutorials it gives, those cover most things IIRC.

If you're used to something like Cities: Skylines, something that tripped me up at first was how public transport works: it's one way, with the return trip being abstracted away, so you don't need to worry about making sensible return trips. Workers are also generic within their skill level, and IIRC follow a logic that's something like trying to go to work within walking distance, or go to a mass transit loading stop within walking distance and then check every time whatever they're on stops until they can find a place to go work; I believe the shopping and entertainment seeking logic is the same. AFAIK they don't plan out trips in advance or intelligently navigate the networks to reach a specific goal the way cims in C:S do, they just go to the job factory and sometimes the job factory is a bus.

The power and water systems are also more complicated than other city builders, because you have to break up power grids between high voltage long distance backbone lines and more limited low voltage local grids, and you have to worry about water pressure and water treatment and separate sewer lines that have to flow downhill because those aren't pressurized.

If you've played Factorio and understand its trains, then you should be able to handle Workers and Resources's trains because IIRC they're similarly complex in practical terms.