I don't know how much more context there was, I found this on the Variety article about it whom he made the comments to, he did say it in kind of a lib way, but maybe he just knows his audience:

“This is time for a revolution — and they don’t even know that’s what they’re starting,” the actor told Variety on Tuesday night at the Sundance Film Festival. “We have to stand up to it. They can’t take us all down. If the whole world showed up on Putin’s doorstep or the Iranians’ doorstep or in Washington, they’d kill 500 or 50 million or however [many], but the rest of us would survive with a new [world].”

“Some very rich old white men are exerting their power to suppress our own people, thus creating a feeling of civil war in the streets, preparing the haters to hate, teaching them how to shoot,” Esposito said. “This is all a preparation for a very insidious problem that’s happening in our world. And for me, I have to speak out. We will not be ICE’d out. This is not going to happen.”

https://variety.com/2026/film/news/giancarlo-esposito-revolution-white-house-ice-1236643679/

He says a bit more on the video after that but basically just concluding.

I doubt he means "it's time for the workers to seize the means" but it's hard to really glean exactly how he means it from such a short clip.

Schrödinger's Shorts.