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submitted 3 days ago by fossilesque@mander.xyz to c/science_memes@mander.xyz

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[-] ranzispa@mander.xyz 39 points 3 days ago

Grant proposal:

salaries: 100k
fish tank and equipment: 20k
chemical supplies: 500k
animal acquisition and maintenance: 50k

We justify the expenditure in this study with the need to repeat the experiment up to 500 times to reach statistical significance. The ethics committee approved the project after testing the sample of preliminary evidence we provided them with.

[-] turtlesareneat@piefed.ca 14 points 3 days ago

The animal welfare committee has concluded the most humane way to coke up the fish is for the researchers to also do a few bumps so they feel like it's a party.

[-] Midnitte@beehaw.org 14 points 3 days ago

You make this joke, but Im sure there are conservatives already harping on this as a waste of money- meanwhile its super valuable to know the effective of human waste on fish behavior to help mitigate the damage

[-] night_petal@piefed.social 3 points 2 days ago

Like the shrimp on the treadmill.

[-] ChicoSuave@lemmy.world 31 points 3 days ago

Is the Swedish study that tested cocaine in salmon and found the cocaine fish swam further than sober fish but both swam less than the salmon who ingested metabolized cocaine surprisingly swam the furthest. This is important because it shows human drug use is screwing up nature. The metabolized cocaine is benzoylecgonine found in human urine and it is being absorbed by the fish. It's super interesting to see how even on dry land humans can change the sea without trying.

[-] jaybone@lemmy.zip 14 points 3 days ago

Are people really using enough cocaine that its impact on the ocean is significant? Like I’m guessing a lot of people drive a car, which I’m guessing is a lot worse than cocaine.

[-] cenzorrll@piefed.ca 11 points 3 days ago

Benzoylecgonine is very stable. It can in fact be analyzed in tap water in communities that recycle waste water to determine how much cocaine is being used.

[-] ranzispa@mander.xyz 3 points 2 days ago

Indeed, but it is a fair question to ask: what is the actual concentration in the ocean? I did not read the study, possibly they used a concentration similar to the one encountered in oceans.

[-] Cethin@lemmy.zip 4 points 2 days ago

Seeing as this is about salmon, it's probably more relevant to ask about the concentration in rivers. A river downstream from a reasonable size city likely has a not insignificant level. I assume the ocean is effectively nothing though.

[-] chuckleslord@lemmy.world 22 points 3 days ago

This was actually a really good study. While cocaine certainly fucks them up, it's actually the human-cocaine metabolite that's more impactful! So, ya know, we gotta make sure we're doing waste water treatment so as to not fuck over the fish from the Saturday night, town-wide benders y'all keep having.

[-] Coldgoron@lemmy.zip 13 points 3 days ago

My adhd ass watching as fish get better stimulant medication than I can get. Life is chaos lmao.

[-] village604@adultswim.fan 11 points 3 days ago

Cocaine is a pretty shitty ADHD medication. Meth would be more effective.

[-] CapuccinoCoretto@lemmy.world 11 points 3 days ago* (last edited 3 days ago)

Fun fact time because I'm that guy.

Coke and meth are similar in that they both activate stimulate Dopamine (reward, motivation), Norepinephrine (arousal, alertness) Serotonin (mood, modulation).

However they do it in very different ways:

Cocaine blocks neurotransmitter reuptake from the outside, it stops the neurotransmitter from being released from the synapse causing the area to flood and the synapse to fire more strongly, but still tied to normal stimulation. I.e. your body still produces the transmitter based on normal stimuli, coke just keeps it there longer, stretching the existing signal.

Methamphetamine drives release from the inside. It pushes dopamine out and into the synapse, and has some reuptake inhibition that combines drive the synapses far harder than normal. In contrast to coke, it doesn't stretch existing signals from physiological stimuli, it makes signals regardless of what's going on.

In short, coke blocks the sink's drain. Meth turns on the tap and sorta plugs the drain. Slight advantage to meth here for ADHD. CNS depression that underlies it responds better to meth because the taps don't open enough to begin with. Normal psysiological stimuli isn't enough.

Both in theory could treat ADHD, but meth wins by a longshot because of the speed and stability of its pharmacokinetics. Coke is in and out too fast to give the user the therapeutic window of relief without causing spikes that trigger negatives like addiction or heart problems. Meth is slower and longer lasting. 20-60 mins for coke, ~4 hours for meth. Leveraging extended release (er) formulations pushes meths already superior action (turn on tap) into a daily therapeutic window, while coke is still just behaving like a party drug.

Source: Lots of personal research. ( ͡° ͜ʖ ͡°)

[-] village604@adultswim.fan 6 points 3 days ago

I learned the cocaine thing the second time I tried it (first was just a bump at new years that kept me from getting drunk).

My friends were bouncing off the walls having a great time while I sat there and tripled my high score in Snake. I remember thinking, "this is like a shitty Adderall."

[-] Dyskolos@lemmy.zip 2 points 3 days ago

snorts a line....STOP JUDGING MY LIFE CHOICES MAN!

[-] yakko@feddit.uk 5 points 3 days ago

I heard that they were trying to get the WHO to decriminalise coca leaf. Would be great if a cup of tea could replace a controlled substance for ADHD treatment. More research needed ofc but hey, it's hopeful

[-] Apocalypteroid@anarchist.nexus 14 points 3 days ago

Just won't stop talking utter shit

[-] RaoulDuke85@piefed.social 3 points 3 days ago

And taking shits

[-] wurstgulasch3000@feddit.org 7 points 3 days ago

shocked pikachu face

[-] OpenStars@piefed.social 4 points 3 days ago

[-] Gork@sopuli.xyz 4 points 3 days ago

I'm sure salmon would love that when they're swimming upstream back to their spawning pools.

[-] GregorGizeh@lemmy.zip 5 points 3 days ago* (last edited 3 days ago)

Some days ago there was literally an article about this shared around here that says the coked up salmon are swimming for longer and further for their mating season.