In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

Reference: “Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration” by Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau and Nidhi Bhutani, 27 November 2025, Science. DOI: 10.1126/science.adx6649

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[–] 110 points 8 months ago (10 children)

Holy shit. Directly treating the cause of cartilage loss with pill-form treatment in human trials right now. The shit we've been doing with medical science recently is fucking wild.

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  • [–] 17 points 8 months ago (8 children)

    Would've been useful before I had my foot cut off. 🤷‍♂️

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  • [–] 22 points 8 months ago (6 children)

    In 20 years you'll get a pill from the pharmacy to grow a new one 😋

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  • [–] 7 points 8 months ago (5 children)
  • [–] 13 points 8 months ago (3 children)

    TONIGHT ON DEAL OR NO DEAL:

    you can get this new leg but it will cost you a kidney

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  • [–] 53 points 8 months ago (17 children)

    As a 50+ year old mechanic, this can’t come soon enough.

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  • [–] 19 points 8 months ago (1 child)

    Wow yes. So many older and retired workers from the skilled trades could benefit from this.

    It would also be a huge boon for recruitment as I imagine young people considering the career may be discouraged by the physical demands of the job and their potential lasting effects.

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  • [–] 10 points 8 months ago (6 children)

    Perfect for making you work the remainder of your life. No more arthritis? Great, now work until death to pay for it.

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  • [–] 8 points 8 months ago (6 children)

    Spoiler alert: you can't afford it.

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  • [–] 30 points 8 months ago (1 child)

    The rich are going to live well

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  • [–] 28 points 8 months ago
    [–] 21 points 8 months ago (3 children)

    Bet soon I can buy this from a roided up guy in the locker rooms of my local gym. Middle aged power lifters would love to pop these pills.

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    [–] 15 points 8 months ago (5 children)

    Between this and growing new teeth, things are looking a lot more cyberpunk than before.

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  • [–] 6 points 8 months ago (3 children)
  • [–] 15 points 8 months ago (1 child)

    So…there’s a chance I can back into martial arts? Bring it.

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  • [–] 7 points 8 months ago (2 children)

    What the fuck? All we ever needed was a pill? Is everybody stupid?

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  • [–] 7 points 8 months ago (1 child)

    Damn mice's at this point they will reach immortality first. Then again thankful for that lol.

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  • [–] 4 points 8 months ago

    I wonder if you'd have to stay off of those joints for months to allow the regrowth to occur properly.

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  • [–] 3 points 8 months ago* (2 children)

    The question is "Does 15-PGDH do something beneficial and would suppressing it have serious side effects?"

    I found this:

    15-HPGD has an unappreciated role in the maintenance of pregnancy. In mice, 15-HPDG has been shown to have essential roles in prevention of early termination of pregnancy and maternal morbidity. In 15-HPGD knockout mice, early pregnancy termination was detected.

    So any 15-HPGD treatment would have to be done with careful consideration of woman of reproductive age.

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