I think lemmy.world is in a great position because the admin has experience hosting decentralized platforms and already has a good pipeline to cover server costs because of that.
lemmy.ml is also the first instance that I joined. I don’t think lemmy.ml should drop off. Since it’s run by the lemmy devs I think they have their hands more than full at the moment, but I’m hopeful that things will stabilize eventually and they will get more financial support with the new users.
I think it’s important to have at least a few big populated instances that are “main” instances. I like what I see with lemmy.ml, lemmy.world, and beehaw.org. Personally I think it’s bad if we are too centralized on one instance or too spread out on a bunch of others. It seems like it’s going fairly well so far though, and I hope that when other big instances keep growing (and like I said get some more financial support from the community) they can improve their hardware too.