Yakko from the Animaniacs, though he may be a bit too smart for the job.

Just for the comedy that might ensue from how horrible of a president he'd be, my vote is Principal Dr. Cinnamon J. Scudworth with Buttlertron as his VP.

Either that, or if possible, as a slightly more serious answer, why not have someone like an actual scientist like Professor Professor from The Secret Show with Name Changed Daily as the VP ( or vice versa )? They already run a not-so-secret spy organization, so why not?

Hobbes

Satsuki Kiryuin, fuck it she might get our shit together.

Scrooge McDuck (Duck Tales version). Dude knows how to manage people and balance a budget. Sure he might occasionally get obsessed with some treasure in the middle east but that's no different than most presidents.

Nausicaä of the Valley of the Wind

E: Always forget the diacritical marks

OG Jesse Custer from The Preacher comic series, not the sanitized version from the series.

Daria

Bill Cipher

Jesus of Nazareth

Captain planet.

Maybe we'd finally actually do something about climate change and for an extra special bonus we get to see him kick the shit out of the likes of the Koch's and whatever demon spawn runs Nestle.

Side note: mufasa is my namesake! I'm just so super creative and ran it backwards lol

Uncle Iroh, but post general/fire lord.

Hermes Conrad. He's got a level head and knows his way around a bureaucracy.

Winnie the Pooh for the irony

You know, cause they keep calling some other head of State that

There was a Karl Marx anime, so anime Karl Marx 👀

@Melatonin Since you lot can't be trusted I'm calling in Princess Twilight Sparkle to take you back to a monarchy.

Jessica Rabbit.

All those "women can't be president" douchebags would shut the fuck up and start becoming "nice guys" which would be cringy but at least it would get them to stop sabotaging the rest of us.

King Julien. No one comes close.

Keith David's president from Rick and Morty, because of the soothing baritone.

I'm going to cheat a little and say Captain Kirk from Star Trek TAS

Poison Ivy from Harley Quinn.

Daria

The coyote from Road Runner. He comes up with plans, some simple, some complex, and they always fail to work. Oh wait…