“Hand-written assembly” is not more powerful than any other Turing-complete language (including Perl and Python), just more painfully slow and prone to human error to write. (Perhaps if you have a special case requiring speed (such as the processing being done in a tight loop in a financial trading app and the results needing to beat rival trading systems by milliseconds or something equally esoteric), it’d make sense, but in that case, a modern compiler (for, say, C/C++/Rust or similar) would yield comparable results, and if a lot is riding on those milliseconds, you’d eschew code and build a FPGA that pulls the data out of memory buffers in hardware or similar.)
So these days, the only use case for hand-writing assembly language (other than low-level OS/firmware programming or compiler development) is performative Feats Of Strength, where the challenge is the point. And in that case, you’d be trying to do something heroically challenging, like writing an Atari 2600 demake of Baldur’s Gate or something.