if the rules are 'you are a normal human on the planet earth', then i pick either LANCER (almost exact same benefits as star trek, but with MECHA) or warhammer 40k.

40k might be a controversial pick, but Holy Terra is probably the safest comfiest place in the entire setting outside of like Eldar craftworlds or Tau space. like worst case scenario you are a relatively well-kept and relatively appreciated servitor cyborg, a living part of the planet/temple to the god-emperor of mankind. best case scenario you work for the High Lords of Terra in some administrative capacity. either way you avoid basically every downside to the 40k setting and still get cool technology and your proximity to the Emperor likely means your soul will be absorbed by Him rather than eaten by some chaos demon. ~~alternatively it gives you a great opportunity to infiltrate humanities homeworld on behalf of Tzeentch, Lord of Change~~

the real question is whether you prefer to have material comfort or a sense of purpose. star trek gives you the opportunity to do like, diplomatic missions and boring slow paced ship combat to defend the federation, but most people probably just pick it because of the holodeck. LANCER at least still sometimes has ground conflicts (with MECHS) where human scale decisions matter sometimes (unlike in star trek where like 1 guy on the ship makes any meaningful decisions during any conflict and all combat is photon torpedo 2d plane space combat or pointing remote controllers at dudes in polyester zentai suits), and 40k despite dystopia gives you a good sense of purpose and challenge, whether you serve teh emprah or wish to overthrow the corpse-throne's stagnant regime

I'm always baffled by people who would be keen on living in 40k, like I get that someone is going to blurt out the answer of the setting they engage with the most, but it's like saying you'd want to experience the battle of the Somme or something