[-] jet@hackertalks.com 2 points 50 minutes ago
[-] jet@hackertalks.com 1 points 2 hours ago

Drenick et al. demonstrated that, after a 2-month fast in obese subjects, insulin stimulation failed to precipitate hypoglycemic reactions with plasma glucose as low as 9 mg/dl (0.5 mM) [25].

This is really important, when fully fat adapted the human body can exist with massively low blood glucose levels. Well beyond what would be considered a hypoglycemic emergency. This isn't relevant for people just doing ketosis for general health, but it is illustrative of the power of fat adaption. This paper calls it out because its part of a cancer treatment protocol where they create hypoglycemic states in patients.

During prolonged fasting, blood glucose levels below 30 mg/dL (1.70 mM) have been sustained continuously for several months without adverse effects [22, 23].

1

TLDR: People don't need carbohydrates, ketosis isn't dangerous.

It is pertinent to briefly discuss the enduring misconception that glucose itself represents an “absolutely essential”, “universal fuel” in human physiology, which requires nuanced definition and gradation, but has been perpetuated verbatim and may have been incorporated into the physiology education of currently practicing healthcare professionals [1-7].

We must first address the distinction between endogenous and exogenous sources of glucose. Clinical trials and epidemiological studies of very low to zero carbohydrate diets support the statement of the US National Academies of Sciences that “the lower limit of dietary carbohydrate compatible with life apparently is zero, provided that adequate amounts of protein and fat are consumed” [8-11]. Even so, despite seemingly safe and increasingly popular, the long-term effects of a truly “zero” carbohydrate diet (without micronutrient supplementation) are difficult to ascertain through controlled experimentation, being only inferred from evolutionary biology, observational studies, and mechanistic data [12-14]. With this caveat, it has now been clearly established in large cohorts of patients, both adult and pediatric, that the oral intake of carbohydrates can be chronically very low (< 5-10% of total daily energy), as long as essential micronutrients are obtained from the underlying food selection and/or supplementation [15-18].

During fasting or in the absence of dietary carbohydrates, a steady-state euglycemia will be maintained in a low but physiological range via hepatic and renal gluconeogenesis from endogenous sources, such as lactate, fatty acids (glycerol), gluconeogenic amino acids and odd chain fatty acids [19-21]. From an evolutionary perspective, a minimal threshold of gluconeogenesis was preserved even after indefinite periods of fasting, questioning whether glucose itself is essential [22, 23]. It was not until the seminal work of Cahill et al. corroborating the remarkable metabolic flexibility of human physiology that the absolute requirements of glucose under compensatory ketosis could be quantified [24]. Drenick et al. demonstrated that, after a 2-month fast in obese subjects, insulin stimulation failed to precipitate hypoglycemic reactions with plasma glucose as low as 9 mg/dl (0.5 mM) [25]. During prolonged fasting, blood glucose levels below 30 mg/dL (1.70 mM) have been sustained continuously for several months without adverse effects [22, 23]. It is apparent that glucose requirements can be significantly displaced by fat-derived fuels, assuming a gradual period of ketogenic adaptation proportional to the degree of glucose depletion [26, 27]. Most human tissues require at least 1 to 4 weeks of strict KD adherence for the effective upregulation of ketone body metabolism, a process that can be accelerated through water-only fasting [28-30]. Without ketogenic adaptation, glucose is indeed the “primary metabolic fuel”, as evidenced by hypoglycemic reactions after accidental secretagogue or insulin overdose in diabetic patients following carbohydrate-rich diets, even under conditions of diabetic ketoacidosis [31-33].

Many clinicians fear ketosis due to confusion with diabetic ketoacidosis, defined by the triad of excessive ketogenesis, metabolic acidosis and concomitant hyperglycemia [34]. A low level of ketones (e.g., < 0.5 mM) prior to initiating carbohydrate restriction indicates that the individual is likely not deficient in insulin and therefore not at risk for ketoacidosis [35]. Clinicians may wish to monitor serum bicarbonate during the early stages of ketogenic adaptation. Ketoacidosis does not occur unless ketones coexist with hyperglycemia and decreasing bicarbonate levels, indicating insulin insufficiency (not to be confused with insulin suppression via carbohydrate restriction, which in turn increases insulin sensitivity, as indicated by lower insulin requirements for euglycemia) [36].

In the context of KMT, evolutionary competition for the limited nutrient supply between the tumor and normal tissues may be potentiated [37]. It is important to clarify that the uninterrupted maintenance of very low glucose levels (< 3 mM) is not realistically achievable for most patients following isocaloric KDs and typically requires prolonged fasting or pharmacological interventions. Fortunately, the anti-tumoral benefits of KMT are hypothesized to arise from pleiotropic regulation of energy sensing and growth signaling pathways (PI3K, AKT, AMPK/mTOR, PGC-1α), inflammation, angiogenesis, and autophagy, not solely as the result of reduced glucose availability with compensatory ketosis, which simply serves as a surrogate marker for successful clinical implementation [38-43].

Ok, this isn't a whole paper by itself, its an appendix of Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma But its so well written, it deserves to be highlighted.

Full Original Paper here: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4#Sec31 - Supplementary Material 1 - Appendix 1 - Warning - It's a docx document.

references 1-43

  1. Nakrani MN, Wineland RH, Anjum F: Physiology, Glucose Metabolism. StatPearls 2022.
  2. Mathew P, Thoppil D: Hypoglycemia. In: StatPearls [Internet]. edn.: StatPearls Publishing; 2022.
  3. Ritter S: Monitoring and maintenance of brain glucose supply: importance of hindbrain catecholamine neurons in this multifaceted task. Appetite Food Intake 2017:177-204.
  4. Mergenthaler P, Lindauer U, Dienel GA, Meisel A: Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci 2013, 36(10):587-597.
  5. Luz MR, de Oliveira GA, de Sousa CR, Da Poian AT: Glucose as the sole metabolic fuel: The possible influence of formal teaching on the establishment of a misconception about energy‐yielding metabolism among students from Rio de Janeiro, Brazil. Biochemistry molecular biology education 2008, 36(6):407-416.
  6. Ghosh A, Cheung YY, Mansfield BC, Chou JY: Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production. J Biol Chem 2005, 280(12):11114-11119.
  7. Brosnan JT: Comments on metabolic needs for glucose and the role of gluconeogenesis. Eur J Clin Nutr 1999, 53 Suppl 1(1):S107-111.
  8. Lupton JR, Brooks J, Butte N, Caballero B, Flatt J, Fried S: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. National Academy Press: Washington, DC, USA 2002, 5:589-768.
  9. Landry MJ, Crimarco A, Gardner CD: Benefits of Low Carbohydrate Diets: a Settled Question or Still Controversial? Curr Obes Rep 2021, 10(3):409-422.
  10. Goldenberg JZ, Day A, Brinkworth GD, Sato J, Yamada S, Jonsson T, Beardsley J, Johnson JA, Thabane L, Johnston BC: Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data. BMJ 2021, 372:m4743.
  11. Lennerz BS, Mey JT, Henn OH, Ludwig DS: Behavioral Characteristics and Self-Reported Health Status among 2029 Adults Consuming a "Carnivore Diet". Curr Dev Nutr 2021, 5(12):nzab133.
  12. Ben-Dor M, Sirtoli R, Barkai R: The evolution of the human trophic level during the Pleistocene. American journal of physical anthropology 2021, 175 Suppl 72:27-56.
  13. O’Hearn A: Can a carnivore diet provide all essential nutrients? Current Opinion in Endocrinology, Diabetes Obesity 2020, 27(5):312-316.
  14. Klement RJ: Was there a need for high carbohydrate content in Neanderthal diets? American Journal of Biological Anthropology 2022, 179(4):668-677.
  15. Westman EC: Is dietary carbohydrate essential for human nutrition? Am J Clin Nutr 2002, 75(5):951-953.
  16. O’Hearn A, Westman EC, Yancy WS, Wellington N: Nutritional aspects. In: Ketogenic. edn. Edited by Noakes TD, Murphy T, Wellington N, Kajee H, Rice SM: Academic Press; 2023: 71-104.
  17. Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN: Ketogenic diets for drug-resistant epilepsy. Cochrane Database Syst Rev 2020, 6(6):CD001903.
  18. Hagstrom H, Hagfors LN, Tellstrom A, Hedelin R, Lindmark K: Low carbohydrate high fat-diet in real life assessed by diet history interviews. Nutr J 2023, 22(1):14.
  19. Chourpiliadis C, Mohiuddin SS: Biochemistry, gluconeogenesis. In: StatPearls [Internet]. edn.: StatPearls Publishing; 2021.
  20. Taherizadeh M, Khoshnia M, Shams S, Hesari Z, Joshaghani H: Clinical Significance of Plasma Levels of Gluconeogenic Amino Acids in Esophageal Cancer Patients. Asian Pac J Cancer Prev 2020, 21(8):2463-2468.
  21. Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI: Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 1991, 254(5031):573-576.
  22. Stewart WK, Fleming LW: Features of a successful therapeutic fast of 382 days' duration. Postgraduate medical journal 1973, 49(569):203-209.
  23. Thomson TJ, Runcie J, Miller V: Treatment of obesity by total fasting for up to 249 days. Lancet 1966, 2(7471):992-996.
  24. Cahill GF, Jr.: Fuel metabolism in starvation. Annual review of nutrition 2006, 26:1-22.
  25. Drenick EJ, Alvarez LC, Tamasi GC, Brickman ASJTJoci: Resistance to symptomatic insulin reactions after fasting. 1972, 51(10):2757-2762.
  26. Longo R, Peri C, Cricri D, Coppi L, Caruso D, Mitro N, De Fabiani E, Crestani M: Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry. Nutrients 2019, 11(10):2497.
  27. Zhang Y, Kuang Y, Xu K, Harris D, Lee Z, LaManna J, Puchowicz MA: Ketosis proportionately spares glucose utilization in brain. J Cereb Blood Flow Metab 2013, 33(8):1307-1311.
  28. Burke LM, Whitfield J, Heikura IA, Ross ML, Tee N, Forbes SF, Hall R, McKay AK, Wallett AM, Sharma AP: Adaptation to a low carbohydrate high fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability. The Journal of Physiology 2021, 599(3):771-790.
  29. Phinney SD, Bistrian BR, Wolfe RR, Blackburn GL: The human metabolic response to chronic ketosis without caloric restriction: physical and biochemical adaptation. Metabolism 1983, 32(8):757-768.
  30. Kackley ML, Brownlow ML, Buga A, Crabtree CD, Sapper TN, O'Connor A, Volek JS: The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults. Front Neurosci 2022, 16:971144.
  31. Pathak RD, Schroeder EB, Seaquist ER, Zeng C, Lafata JE, Thomas A, Desai J, Waitzfelder B, Nichols GA, Lawrence JM et al: Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S. Integrated Health Care Delivery Systems: 2005-2011. Diabetes Care 2016, 39(3):363-370.
  32. Chantzaras A, Yfantopoulos J: Evaluating the Incidence and Risk Factors Associated With Mild and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes. Value Health Reg Issues 2022, 30:9-17.
  33. Ben-Ami H, Nagachandran P, Mendelson A, Edoute Y: Drug-induced hypoglycemic coma in 102 diabetic patients. Archives of internal medicine 1999, 159(3):281-284.
  34. Dhatariya KK, Glaser NS, Codner E, Umpierrez GE: Diabetic ketoacidosis. Nat Rev Dis Primers 2020, 6(1):40.
  35. Cooper ID, Brookler KH, Kyriakidou Y, Elliott BT, Crofts CAJB: Metabolic phenotypes and step by step evolution of type 2 diabetes: A New paradigm. 2021, 9(7):800.
  36. Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, Hong D, Tian S, Sun C: Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis. Nutr Diabetes 2020, 10(1):38.
  37. McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB: Chronic hypoglycemia increases brain glucose transport. Am J Physiol 1986, 251(4 Pt 1):E442-447.
  38. Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN: Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Br J Cancer 2002, 86(10):1615-1621.
  39. Mukherjee P, Mulrooney TJ, Marsh J, Blair D, Chiles TC, Seyfried TN: Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Mol Cancer 2008, 7:37.
  40. Mulrooney TJ, Marsh J, Urits I, Seyfried TN, Mukherjee P: Influence of caloric restriction on constitutive expression of NF-kappaB in an experimental mouse astrocytoma. PLoS ONE 2011, 6(3):e18085.
  41. Shelton LM, Huysentruyt LC, Mukherjee P, Seyfried TN: Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. ASN Neuro 2010, 2(3):e00038.
  42. Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN: The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr Metab (Lond) 2007, 4:5.
  43. Wong W: Mitochondrial fission fueled by fasting. Sci Signal 2023, 16(797):eadk1008.

The image in the post is from Resistance to Symptomatic Insulin Reactions after Fasting which is reference 35.

[-] jet@hackertalks.com 3 points 3 hours ago

Ahh! let's talk about ought!

Since humans store fat, one could see mechanistically we are setup to run on the energy we store: fat

When humans go more then 4 hours without eating glucose (skipping a meal, keto, fasting, or sleeping) they are running on fat, including the brain. If you want to prevent your brain from using fat you need to drip feed glucose all day (which some people try really hard to do), but when you sleep some of that fat will finally get to be used by the brain. One could reasonably argue the default energy of the human body is fat, hence why it's used during sleep.

https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2016.00053/full#h7

Both short-term PET and arterio-venous difference studies in humans show that brain glucose consumption decreases as ketone availability to the brain increases. These results suggest that ketones are actually the preferred energy substrate for the brain because they enter the brain in proportion to their plasma concentration irrespective of glucose availability; if the energy needs of the brain are being increasingly met by ketones, glucose uptake decreases accordingly. This decrease in brain glucose uptake when both ketones and glucose are available supports the notion that ketones are the brain’s preferred fuel.

The body will use glucose when available, because glucose is so damaging to cells - glycation happens rapidly. As soon as any glucose elevations are seen in the blood stream insulin is immediately released to push glucose into fat cells and get blood glucose levels back to the low normal.

However, I'm open to being wrong: Why 'ought' the brain use glucose instead of fat?

[-] jet@hackertalks.com 2 points 3 hours ago

Arne Høygaard, Studies on the Nutrition and Physio-Pathology of Eskimos, undertaken at Angmagssalik, East-Greenland, 1936–1937 - https://www.nb.no/items/c73c89a07af4f6285f497a212e56e92e

Need a Norway IP address, but the full book is online

[-] jet@hackertalks.com 2 points 3 hours ago
[-] jet@hackertalks.com 2 points 3 hours ago
2

Dr. Michael R. Eades received his BSCE degree in Civil Engineering from California Polytechnic University (Cal Poly), Pomona, California and his MD from the University of Arkansas Medical Sciences (UAMS).

After completing training in General Surgery as UAMS, Dr. Eades (along with his wife) founded Medi-Stat Medical Clinics, a chain of general family medicine outpatient care centers in central Arkansas, where he practiced general family medicine for over a decade.

In 1996, Dr. Eades co-authored (with Mary Dan Eades, MD), their first joint book project 'Protein Power', which became a national and international bestseller, selling over 3 million copies and spending 63 weeks on the NY Times Best Seller List.

summerizerHistorical challenge

  • Plant-based messaging is cast as the old low-fat campaign in new clothes and as pressure away from low-carb eating.
  • Bread-centered stories about traditional Western diets are rejected; nineteenth-century meat markets, menus, and the Titanic menu are used as proof that meat was abundant before the twentieth century.
  • The central practical rule is evolutionary: the diet that shaped human physiology is the diet human beings do best on now.

Clinical and trial bridge

  • Blake Donaldson’s all-meat practice is a modern clinical echo of a much older human pattern.
  • Mark Nathan Cohen’s warning is that medicine mistakes recent Western experience for the full range of human biology.
  • Modern randomized trials are added to the anthropological record, and the low-carb side is the clear winner over low-fat diets.

Brains, guts, and energy

  • Leslie Aiello’s expensive-tissue hypothesis and Max Kleiber’s metabolic work anchor the main mechanism.
  • Humans have a metabolically expensive brain and a reduced gut, so the human body plan does not fit a bulky plant-based diet.
  • Meat solves the energy problem by shrinking gut demands and freeing metabolic budget for a larger brain.

Plant bulk and scavenging

  • Great apes carry large abdomens because low-density plant foods require a lot of gut volume.
  • Early humans could move into a meat-heavy niche first by scavenging and later by hunting.
  • Briana Pobiner’s lion-kill work shows that large carcasses left enough calories behind to make scavenging a realistic bridge.

Stable isotopes and trophic level

  • Carbon and nitrogen isotope ratios make long-term dietary reconstruction possible after soft tissue is gone.
  • Neanderthals sit at or above the carnivore range in isotope comparisons and are placed at a super-carnivore level.
  • Early modern humans also cluster at a very high trophic level, with animal food dominating protein intake.

Foragers, farmers, and degeneration

  • The Kentucky comparison sets a meat-heavy hunter-gatherer population against a corn-bean-pumpkin farming population.
  • The farming group shows more iron-deficiency lesions, enamel defects, caries, abscesses, periosteal disease, infant mortality, and shorter life.
  • Agriculture turns intermittent stress into chronic degeneration, while the foraging group shows better baseline health.

Cariogenic plants and agriculture

  • Severe dental destruction can come from heavy reliance on starchy or otherwise cariogenic plant foods even without refined sugar.
  • Jared Diamond’s verdict fits the skeletal record: agriculture is a biological catastrophe rather than a health advance.
  • A plant-focused side branch with massive chewing anatomy dead-ended, while the Homo line moved toward more meat and more brain.

Egypt as a natural experiment

  • Ancient Egypt functions as a long-running wheat-based civilization trial centered on bread.
  • Bread, fruits, vegetables, honey, seed oils, fish, waterfowl, and only occasional red meat create a pattern equivalent to a modern low-fat prescription.
  • Egyptian statuary is read as evidence of abdominal obesity and male breast enlargement.

Egyptian disease burden

  • Mummies and papyri put heart disease, catastrophic dental wear, obesity, and diabetes-like illness deep in antiquity.
  • Marc Armand Ruffer’s autopsies, the Ebers Papyrus, CT scans, and the Horus study place vascular disease throughout ancient Egypt.
  • Attempts to blame elite saturated-fat intake fail once isotope work shows similar diets across social classes and less than half of protein from animal sources.

Final synthesis

  • Metabolic theory, scavenging ecology, stable isotopes, paleopathology, Egyptian mummies, and randomized trials all converge on the same answer.
  • Human beings are built for a lower-carbohydrate, meat-heavier diet than agricultural and modern plant-centered orthodoxies allow.
  • The practical prescription is blunt: cut the carbs.

References

[-] jet@hackertalks.com 2 points 4 hours ago

Sure, humans are lipvores we store fat we run on fat, stored fat is often seen as weight.

Regardless if a person is skinny, fat, or in between their brain can run on fat.

[-] jet@hackertalks.com 1 points 4 hours ago
[-] jet@hackertalks.com 3 points 5 hours ago

The talk about WWII women gaining fat while their families were starving was heart breaking (around the 32m mark)

[-] jet@hackertalks.com 2 points 5 hours ago

I'm not talking about your weight, I'm talking about the fuel source for the brain. The body runs on fat, the brain runs on fat. It can, when available, also use glucose - but the entire metabolic system tries to keep glucose levels low and consistent rather then spiked and high.

[-] jet@hackertalks.com 1 points 5 hours ago

I did some poking into Dr Glandt's publication history:

  • 2025 — Myths and Facts Regarding Low-Carbohydrate Diets. Summary: review/opinion paper addressing common claims about low-carbohydrate and ketogenic diets. DOI: https://doi.org/10.3390/nu17061047

  • 2024 — Use of a very low carbohydrate diet for prediabetes and type 2 diabetes: An audit. Summary: clinical audit of a very-low-carbohydrate ketogenic program for prediabetes and type 2 diabetes. DOI: https://doi.org/10.4102/jmh.v7i1.87

2

TLDW - With medical supervision T2D can be reversible using a ketogenic nutritional therapy.

Type 2 diabetes doesn’t just need to be managed; it can be reversed.

For years, endocrinologist Dr. Mariela Glandt followed the conventional playbook: carefully adjusting medications, prescribing the latest drugs, and urging patients to eat whole grains and lean proteins. Yet her patients kept getting sicker, medications piled up, and their diabetes was treated as an inevitable, “progressive” disease.

Then came a turning point.

Through her research, Dr. Glandt came across scientific evidence that showed we could address insulin resistance head-on: by removing excess carbohydrates, patients could actually reverse their condition. No longer bound to insulin injections and endless prescriptions, they could reclaim their health.

summerizerClinical shift

  • Years of diabetes care focused on glucose targets, medication adjustment, and newer drugs while patients remained under escalating medication burden.
  • Standard advice about the gym, whole grains, lean meats, fruits, and vegetables did not get patients off medications.
  • Type 2 diabetes can be reversed when insulin resistance is the root cause. Mechanism and diet
  • Type 2 diabetes is the body reaching a limit with sugar and carbohydrate load.
  • Carbohydrate removal removes the offending agent and diabetes fades.
  • Carbohydrates are not essential nutrients because the liver makes the glucose the body needs through gluconeogenesis.
  • A well-formulated low-carbohydrate diet is rich in natural proteins and fats.
  • Blood sugar goes down, normalizes, the body heals, and medications are peeled away. Patient impact
  • The first patient on the protocol lost 60 pounds in 6 months, dropped A1C from 10 to 5.4, and stopped every medication, including insulin.
  • The deeper change is fear lifting, hope returning, and health no longer feeling like a personal failure.
  • Seeing that change makes return to the earlier approach impossible.

Scaling and evidence

  • Ketogenic diet use or therapeutic carbohydrate restriction reached about 4,000 patients before Ona Health was founded to scale the work, especially for Medicaid patients.
  • This approach reverses diabetes at a fractional cost of traditional therapies.
  • The country carries tens of millions of diabetes and prediabetes cases plus downstream costs from amputations, heart attacks, dialysis, depression, and the rest of the burden of type 2 diabetes.
  • Ketogenic diets are therapeutic, medicinal, and curative.
  • The evidence is strong enough that this approach would have received FDA approval long ago if it had been a drug.
  • ADA consensus language puts carbohydrate reduction at the top of the evidence base, and Tracey Brown reversed her own diabetes with a ketogenic diet.

Policy and access

  • A humane and affordable option already exists that targets root cause, gives energy, lowers sugar cravings, and creates lasting satiety.
  • Federal and Medicaid pilots can spread this model across the country.
  • Food as medicine can expand access to healthy food and reverse chronic disease at scale.
  • The evidence is already in hand, the tools already exist, and the time is now.

References

This talk is just a sampler, and it should be noted virta health is doing the bulk of the t2d reversal publications.

ADA Quote - "Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report" - http://doi.org/10.2337/dci19-0014

Reducing overall carbohydrate intake for individuals with diabetes has demonstrated the most evidence for improving glycemia

[-] jet@hackertalks.com 2 points 6 hours ago

Starches and carbs feed the brain.

Turns into blood glucose, which the body can use in the brain, but works as hard as it possibly can to put into fat cells. The brain also runs perfectly well on fat, humans store fat not glucose for long term energy.

0

Dr. Donese Worden, NMD joins Professor Seyfried for an in-depth conversation covering the most important scientific findings and treatment tactics for managing cancer metabolically.

summerizerCancer crisis and the new organization

  • Cancer deaths and projections remain severe enough that metabolic oncology needs organized bench-to-bedside research, education, and clinician support.
  • The new nonprofit joins researchers, oncologists, and physician scientists to move metabolic oncology forward with rigor and integrity.
  • Laboratory validation and patient care refine the same metabolic plan together. Finding a capable metabolic oncology clinician
  • A strong clinician knows the mitochondrial metabolic theory, stays current with Seyfried and related research, and can explain the field fluently.
  • Experience matters, but the key test is whether the clinician can individualize care for two patients with the same diagnosis.
  • A one-size-fits-all protocol is a warning sign.
  • Vague answers, defensiveness, overconfidence, and cure promises are reasons to leave.

Core metabolic oncology plan

  • The press-pulse strategy is the working plan, and clinicians flesh it out in real patients while laboratory and clinical work keep improving it.
  • Ketogenic diet or at least low carbohydrate intake is foundational for most patients, alongside stress reduction, exercise, careful nutraceutical use, repurposed drugs, and often hyperbaric oxygen.
  • Nutritional ketosis is the platform, and the practical target is a glucose-ketone index around 2.0 or lower.
  • Multiple restricted dietary patterns can reach nutritional ketosis, including Mediterranean, carnivore, pescetarian, and vegan diets.
  • Time spent in the zone matters more than perfection, and flexibility matters because some patients feel tortured by chasing a perfect GKI.

Stress, patient agency, and education

  • Stress management is a central part of cancer care because cancer-related stress raises corticosteroids and can make ketosis harder to reach.
  • Music, massage, acupuncture, meditation, breath work, exercise, and other stress-lowering practices belong on the clinical menu.
  • Patients do better when they take an active role in their care and come prepared to learn.
  • Random internet protocols and self-experiment stacks create confusion, liver strain, contraindications, and wasted effort.
  • Patients need a clinical guide who can choose the right tool, dose, and timing for the person in front of them.

Supplements, vitamins, and personalization

  • Supplement quality is a major problem because many products are mislabeled, adulterated, or contaminated.
  • More is not better with supplements or vitamins, and excess vitamins can also feed tumor cells.
  • Supplement use needs a defined reason such as correcting a verified deficiency or exploiting a known vulnerability in cancer cells.
  • Metabolic oncology is highly personalized because bodies, lifestyles, sizes, deficiencies, and response patterns differ. Finding clinicians and building standards
  • The current clinician supply is small, so interim referral points include lists maintained by Seyfried and Dominic D'Agostino.
  • The long-term goal is certification of clinicians, clinics, and labs that can apply metabolic oncology knowledgeably and without compromising standard of care.
  • These practices also fit prevention and chronic disease risk reduction, not only advanced cancer care.
  • Supplement effects and other adjuncts still need broader logging and study across diverse patients.
  • People with cancer often arrive far from metabolic homeostasis, and bringing them back toward homeostasis improves the chances that repurposed drugs and procedures help.

References

1
double post - delete. (www.youtube.com)
submitted 2 days ago* (last edited 2 days ago) by jet@hackertalks.com to c/ketogenic@discuss.online

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3

Only nine scientists were asked to advise on the 2025 Dietary Guidelines for Americans, and Dr. Tom Brenna was one of them. In this conversation, he pulls back the curtain on how dietary guidelines are actually made, why the process has never been the same twice, and what it was like to watch a decades-old saturated fat recommendation get carried forward despite a lack of evidence supporting it at the level of total mortality. This is the dietary guidelines conversation the internet has been missing: straight from someone who was actually in the room.

summerizerCommittee scope and public record

  • The advisory committee handled narrow assigned topics and did not write the final Dietary Guidelines for Americans.
  • Saturated fat was Brenna’s assigned topic in the 2025-2030 cycle, and he had also advised earlier guideline cycles.
  • The committee’s scientific questions, methods, and evidence files were online for public review.
  • The advisory committee delivered a circumscribed scientific document, and federal agencies drafted the final guidelines afterward.
  • Brenna saw the final guideline draft only shortly before release and did not build the upside-down pyramid.
  • The American Society for Nutrition backed the broad whole-food pattern while objecting to departures from the established review process.

Historical roots of the saturated-fat problem

  • The butter-versus-margarine fight predates 1900 and sits behind much of the later saturated-fat story.
  • Partial hydrogenation turned liquid oils into solid fats and created trans fats.
  • Crisco came from partially hydrogenated cottonseed oil and became a major baking fat.
  • Europe used partially hydrogenated whale oil and then partially hydrogenated fish oil in margarine through the mid-20th century.
  • A 1940s margarine film on YouTube shows ingredient streams that include a drum marked "Hardened Whale."
  • Many old diet trials that are used as saturated-fat evidence belong to that same era of hardened marine oils.
  • One cited control-group example carried an estimated 40 to 50 grams per day of hardened marine oils.
  • Those chemically altered fats were not ordinary butter or dairy fat and entered brain and retina.

Definitions, dairy, and policy contradictions

  • "Saturated fat" became a code word for dairy in ordinary nutrition talk.
  • Dairy evidence does not line up cleanly with the generic saturated-fat warning.
  • The 10% saturated-fat cap stayed in place even while school-lunch law excluded fluid milk from the weekly saturated-fat limit.
  • Whole milk in school lunch therefore sits outside the same saturated-fat budget that still governs the rest of the policy.
  • Beef fat is not a pure saturated-fat block here because a large share of beef fat is monounsaturated.
  • Fresh red meat and processed meat do not belong in one undifferentiated category here.

Mortality, stroke, and trial quality

  • The 10% limit drives people away from nutrient-dense foods that carry zinc, selenium, and B12.
  • Total mortality comes ahead of cause-specific endpoints in the evidence hierarchy used here.
  • Randomized trials and prospective cohorts do not show an effect on total mortality in the 2025 review summary given here.
  • What is called saturated fat shows a protective association with stroke in the prospective cohorts cited here.
  • Cause-specific cardiovascular outcomes do not close the case when total mortality does not move.
  • The old randomized diet trials were not double blinded, and participants knew which foods or oils they were getting.

LDL, triglycerides, and population context

  • Sky-high genetically driven LDL is a real problem and sits in a different category from ordinary population shifts.
  • The key open issue is whether moderate LDL reductions below 160 meaningfully change outcomes.
  • Japanese population data serve as an example in which the cholesterol-heart disease pattern runs opposite the usual U.S. expectation.
  • The share of the population above LDL 160 narrows to about 5% to 7%, not the larger number floated earlier.
  • Elevated triglycerides above 200 reach a bigger share of the population in this exchange.
  • Triglycerides here point toward carbohydrate load, insulin resistance, and low omega-3 intake.
  • Fish oil lowers triglycerides here and becomes the example of a pseudo-pharmacologic intervention at very high levels.

Pregnancy, fish, DHA, and the developing brain

  • Fish avoidance during pregnancy removes DHA during a period of rapid brain development.
  • Children of women who eat some fish in pregnancy do better than children of women who eat none on most tests in this telling.
  • The benefit curve rises and then plateaus across the intake range used here.
  • The Seychelles example goes up to about 100 ounces of fish per week without a detectable mercury-harm signal.
  • The people who eat the most fish in the world do not produce the iodine-deficiency picture that is contrasted with fish avoidance.
  • Brain DHA accretion continues well beyond birth and runs to roughly age 20, with remodeling probably out to 25.
  • Breastfeeding keeps delivering omega-3 and DHA after birth.
  • DHA entered infant formula in the U.S. in 2001.

Omega-3, omega-6, and oil profile

  • DHA is a 22-carbon, 6-double-bond omega-3 fatty acid.
  • Omega-3 and omega-6 fatty acids use the same enzymes, so imbalance pushes one against the other.
  • High linoleic acid intake acts as a metabolic suppressor of omega-3s everywhere in the body.
  • The current U.S. diet sits on the high-linoleic side here.
  • Some omega-6 is required, and the problem here is excess rather than zero intake.
  • High-omega-6 oils create a larger metabolic demand for omega-3.
  • Lower omega-6 intake makes a given omega-3 intake go farther.
  • Monounsaturated replacement fats rank highest here, and high-oleic seed oils sit near olive oil in fatty-acid profile.
  • Plant names no longer tell the whole story because modern oil crops were bred into multiple distinct fatty-acid profiles.
  • Lower-omega-6 high-oleic oils also gained shelf-life and frying-life advantages here.

Precision nutrition, genetics, and special vulnerability

  • Precision nutrition fits this field better than one number for everybody.
  • Pregnancy, lactation, brain development, and later brain maintenance have different fatty-acid demands than a generic middle-aged adult target.
  • A fatty-acid-desaturase-cluster insertion-deletion variant operates here as a requirement-shaping genetic signal.
  • In the seAFOod work used here, 2 grams per day of EPA for 1 year cut colorectal polyps by about 50% in a certain genotype.
  • Plant omega-3 sources such as flax, chia, and walnuts are not the same as long-chain omega-3 sources here.
  • Vegetarian eating patterns that keep dairy hold omega-6 exposure lower than patterns that swap dairy fat for high-omega-6 oils.
  • Feeding those oils to pregnant animals disrupts multiple brain measures in the offspring.
  • Early human deficiency work in infants put babies on omega-6-deficient diets, produced skin lesions, and reversed those lesions when omega-6 returned.
  • ADHD evidence remains unresolved here, and fish oil is not offered here as a fix.

References

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When your trying to stay clean what triggers your cravings (food noise)?

How do you avoid these triggers, or extinguish them after they activate?

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submitted 1 week ago* (last edited 1 week ago) by jet@hackertalks.com to c/interesting@hackertalks.com

Learn the types of naval mines which Iran has, and why some are harder to sweep than others. Unscripted and unedited, just a real person sharing knowledge.

summerizerRegional context and strategic effect

  • Iran can threaten shipping through the Strait of Hormuz with naval mines, and even a small number of laid mines can function like a toll booth by forcing ships to accept Iranian control over safe passage.
  • No mine strikes are confirmed in the transcript at this point, but the mine threat alone is enough to deter commercial traffic because ships do not need proof of a live minefield to avoid the route.
  • Mine clearance is slow, dangerous, and difficult, so reopening the strait after even limited mining is much harder than preventing the mining in the first place.

How mines are laid

  • Naval mines can be laid from almost any vessel, including small boats, landing craft, merchant ships, helicopters, submarines, and in some cases rockets.
  • A vessel does not need to be a purpose-built minelayer, because simple rails or improvised handling arrangements are enough to roll mines into the water.
  • The large volume of Iranian-linked small craft and commercial traffic in and around the strait creates many opportunities to sow mines without relying on a specialized platform.

Moored contact and influence mines

  • The Maham-1 is a traditional moored contact mine with horns that detonate on impact, and most variants carry about 120 kg of explosive while a smaller shallow-water version carries about 20 kg.
  • These moored mines sink an anchor to the seabed and then float the charge body a few meters below the surface, where they are harder to see and well placed to strike deep-draft tankers.
  • The Maham-3 keeps the same general moored arrangement but uses acoustic and magnetic influence fusing, so it can detonate without direct contact and can sit deeper beneath a ship.
  • Influence fusing also allows delayed arming, long persistence, and ship counters that let a mine ignore earlier vessels and wait for a later target.

Bottom and specialty mines

  • The Maham-2 is a bottom influence mine with a much larger warhead of roughly 350 kg, better concealment on the seabed, and greater resistance to old-style cable-cutting sweeps.
  • Bottom influence mines are harder to certify as cleared because a live mine can remain on the bottom after multiple ships pass overhead if its counter has not yet reached its programmed number.
  • Iran also has a self-propelled bottom-mine concept in which a torpedo-like propulsion unit carries the weapon 10 to 20 km before it settles on the seabed.
  • A fiberglass-cased conical bottom mine copied from the Italian Manta adds another concealment problem because its nonmetallic body is harder to detect and it is suited to shallow water.
  • Rocket-laid mines using a Fajr-5 type launcher trade warhead size and depth effectiveness for very long standoff placement, making them more useful for anchorages, coastal approaches, and gap-filling than for the deepest main channel.
  • A Chinese EM-52 type rising mine would be the most dangerous system mentioned because it can sit deep on the seabed, sense a target, launch upward, and attack laterally from significant distance.

Clearance and operational impact

  • Traditional wire sweeps can still cut the mooring cables of older floating mines, but they do not solve the problem posed by bottom influence mines.
  • Counters, arming delays, mixed mine types, and uncertainty about where mines were laid all expand the time needed to reopen shipping lanes.
  • A handful of mines is enough to almost paralyze traffic because every transit becomes a gamble and every clearance declaration remains open to doubt.

Other Iranian anti-shipping threats

  • Mines are only one layer of the threat, alongside anti-ship ballistic missiles, USVs, drones, artillery, small-boat attacks, and anti-ship missiles.
  • USVs are identified as the main immediate threat to ships, while mines are identified as the hardest threat to clear once they are in the water.
  • Anti-ship missiles, drones, and small boats can damage or harass shipping, but mines have the strongest ability to keep sea lanes closed over time.

Strategic escalation beyond Hormuz

  • Control pressure in the Strait of Hormuz changes the waterway from open international transit into a passage shaped by Iranian coercion over who sails and on what terms.
  • The pressure can spread beyond Hormuz because Iran can encourage Houthi attacks in the Red Sea and thereby threaten both ends of the wider regional tanker route.
  • Combined disruption in Hormuz, Bab el-Mandeb, and the approaches to Suez creates a broader maritime dilemma than a single chokepoint crisis.

References

https://www.youtube.com/watch?v=TMXSDUj-dms

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submitted 1 week ago* (last edited 1 week ago) by jet@hackertalks.com to c/interesting@hackertalks.com
3

The Week Four recap of the events transpiring in the Strait of Hormuz and Persian Gulf covers issues including the latest update from the Joint Maritime Information Center; the major news stories as featured in gCaptain; the latest passages over the past 48 hours via Marine Traffic; and how may the United States used the newly arrived Marines in the area.

The interesting animation is at 14:30, ships going through the toll booth.

Current global fuel prices - https://www.globalpetrolprices.com/gasoline_prices/

summerizerSituation snapshot

  • The Joint Maritime Information Center keeps the Arabian Gulf, Strait of Hormuz, and Gulf of Oman at critical risk.
  • The running count reaches 21 attacks since 1 March, against a historical Strait of Hormuz flow of about 138 ships per day, with only one ship moving on 24 March and zero attacks in the prior 48 hours.
  • Cargo traffic sits in single digits and tanker traffic remains extremely thin, and the eight to 10 tankers mentioned in the president's cabinet remarks do not show up in the count here. Iranian control over passage
  • Iran keeps the strait open for vessels it does not tie to its enemies and blocks or pressures vessels linked to the U.S., Israel, or countries backing their operations.
  • Trump pauses planned strikes on Iran's energy system until 5 April while negotiations remain unclear, and a strike on Iranian energy is a major escalation.
  • Iran imposes a $2 million transit toll, and paying it can create sanctions exposure for companies that do business with countries restricting Iran.
  • Passage now runs through a permission regime that can require crew lists, cargo details, voyage details, bills of lading, and routing near Larak and Qeshm before a ship gets through.
  • A small containership sailing from the United Arab Emirates toward Pakistan is forced to reverse, and later larger vessels also turn back. Red Sea spillover and energy logistics
  • The Houthis move back toward the Bab el-Mandeb and Red Sea picture, and even without new shipping attacks the threat hangs over the Yanbu export surge.
  • Yanbu may be moving about 5 million barrels per day and possibly 7 million, but renewed attacks off western Saudi Arabia would turn that outlet into an expensive and fragile workaround.
  • Fully loaded VLCCs cannot use the Suez Canal, so a Red Sea disruption would force shuttle movements, extra anchorages, and higher costs. Insurance, timelines, and economic pressure
  • The U.S. political-risk insurance program with DFC and Chubb arrives late in week four, after traffic has already stalled and owners have already made other insurance choices.
  • A crisis lasting weeks is already bad, months would be far worse, and the knock-on effects hit bunker fuel, aviation fuel, LPG, LNG, helium, sulfur, urea, DAP, MAP, and household fuel markets well beyond the U.S.
  • Fuel stress is already spreading across countries such as Australia, the Philippines, Pakistan, and India, while the strait still matters to the U.S. because it affects both direct imports and global pricing.

Marine traffic over 26 to 28 March

  • MarineTraffic shows a modest uptick in movement, especially for Indian LPG cargoes, with BW Elm and BW Tyr crossing for India while several bulk, crude, chemical, and gas carriers continue testing the route.
  • Lotus Rising and Sapphira turn back, and the Hong Kong-flagged CSCL Indian Ocean and CSCL Arctic Ocean head toward Larak, stop, and return to the UAE anchorage.
  • The turnaround of the two large Chinese boxships is the clearest sign that safe passage is still unreliable even for ships tied to countries Iran calls friendly.

Military posture and near-term outlook

  • The Tripoli amphibious ready group is in the area, and the southern Omani side of the strait and nearby islands are possible staging areas for Marines to screen traffic and counter Iranian pressure from the north.
  • Abraham Lincoln remains relevant after replenishment, Ford stays delayed by major fire damage, Bush has not yet sailed, and follow-on Marine forces from Okinawa and Hawaii remain part of the possible next steps.
  • The next U.S. move is still unclear, and the overall cabinet messaging looks confused and unsettled.

References

3

TLDW: Costco Bulk Meats (ground beef is still the most cost effective)

summerizerBuying guide

  • Meat shopping gets easier when the cut name, the usable meat, and the price all match up.

Publix

  • Chuck eye gives ribeye-like eating from the chuck at a lower price and looked like a strong buy at Publix.
  • T-bone and porterhouse come from the same cut area; the T-bone has a smaller filet and the porterhouse has a larger filet.
  • When porterhouse and T-bone cost the same, porterhouse gives more value; the shown T-bone had so little filet that it was mostly bone and strip.
  • Ribeye at $17.99 per pound looked reasonable for Publix.
  • Filet mignon at $32.99 per pound looked overpriced, especially with silver skin still left to trim.
  • Petite shoulder tender is tender and good; chuck tender roast sounds similar but is tough and needs long braising.

Walmart

  • Walmart meat arrives pre-cut and not from on-site cutting, which makes selection harder.
  • Some New York strips include a top-sirloin end piece, so the package carries strip pricing for part sirloin.
  • Porterhouse pricing looked high there, but mislabeled porterhouses can still turn up in the T-bone section.
  • Ribeye at about $23 per pound did not look like a bargain.

Kroger

  • A chuck roast with two grain directions and a fat seam through the middle can be split into Denver steak on top and chuck eye on the bottom.
  • Flat iron is inexpensive, tender, flavorful, and a favorite cut.
  • New York strips with a sirloin end piece are worth skipping.
  • Tomahawk looks impressive but adds bone cost at steak pricing.
  • Bacon-wrapped fillets looked like low-grade meat wrapped in bacon.

Target

  • Target had a lot of ground beef, including lean blends and grass-fed options.
  • Pre-cut ribeye at $18.99 looked acceptable against the other stores.

Costco

  • Costco had the strongest beef value in the tour.
  • Whole beef strip loin at $9.99 per pound beat pre-cut New York strip at $12.99 per pound and only needed simple slicing at home.
  • Flat iron packs at $9.99 per pound and whole top sirloin cap at $8.99 per pound stood out as strong buys.
  • Boneless pork butt works for barbecue and is very good for sausage.
  • Costco ground beef is cheap and works well when vacuum sealed into one- or two-pound portions.

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summerizerOrigin and motivation

  • I found carnivore through YouTube after putting a few reels aside at first.
  • A six-month plant-based period was hard for me to maintain.
  • Dr. Anthony Chaffee's material on day-to-day and athletic benefits made carnivore feel relevant to performance, not just weight loss.
  • Zero-carb athletic performance was the question that pulled me in.
  • Weight loss matters, but this became a lifestyle change.

Health background and why change was needed

  • I had a small health scare after three "CO" jabs, recovered, and did not investigate it further.
  • My bigger issue was an unhealthy lifestyle while chasing esports, which led me to neglect my health.
  • Growing up in a large Filipino household with a giant rice cooker normalized overeating for me.
  • Overeating became one of the habits I needed to break.

Starting carnivore and adapting

  • I started around January 2024 and have stayed with it for about two years and some change.
  • I went in cold turkey.
  • The first two weeks were a real adjustment, with gut issues, frequent bathroom trips, and unstable energy.
  • Milk stayed in because I love milkshakes and kept milk within how I was approaching carnivore.
  • After that early adjustment, sleep, recovery, and general day-to-day feeling improved a lot.

Family response and longer-term view

  • My siblings gave mixed reactions, but they understood the case for animal foods as nutrient-dense.
  • They also warned me about cholesterol, how I was feeling, and possible internal damage.
  • My brother Michael was especially supportive and kept checking in.
  • He now eats mostly animal foods himself and feels great on that approach.
  • I am taking this year by year, but I expect to keep eating far more animal foods because my energy stays consistent and I do not crash.

Work, fasting, and daily structure

  • Carnivore plus fasting made me more productive at work because the afternoon dip largely stopped.
  • I usually have coffee in the morning and wait until later to eat, and that helped regulate my tendency to overeat.
  • Meat becoming less appealing once I have had enough feels like my body telling me to slow down.
  • My weekly structure is 500-calorie coffee-and-milk days on Tuesday, Thursday, and Saturday, with bacon, eggs, steak, side meat, and another egg on the other days.
  • My eating days are about 2,500 calories, my lighter days are about 500 calories, and that is far below the 5,000-calorie overeating pattern I used to have.

Food noise, weight loss, and body change

  • Food noise dropped sharply, and I can now watch a movie without constant thoughts about going to the kitchen.
  • Chips and milkshakes used to make it easy for me to eat thousands of calories without noticing.
  • I started at about 220 kg, sit around 150 kg now, and lost 70 kg over two years.
  • I lost about 35 kg in the first year and about 35 kg in the second year.
  • I want another 50 kg off and see carnivore as the best weight-loss tool I have used.
  • Slower loss feels better for body adaptation, and so far loose skin is mostly limited to my stomach and love handles.

How I explain it to other people

  • I tell people the first two to four weeks are hard, so they need to find a version they can actually sustain.
  • My practical advice is to eat animal foods, lean hard on staples like beef, butter, bacon, eggs, milk, honey, and seafood, and take it one day at a time.
  • I see the goal as changing your life, not proving something for 30 or 90 days.

References

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jet

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