the linguistic angle here is genuinely fascinating, and relevant to a lot of this discussion. i think that even when used as discourse markers there's an amount of gender that remains attached, but i see what you're saying
i have to say though, that isn't the biggest issue the post was about. it was about being actually called a dude or a guy by people. a lot of the discussion here was about discourse markers but the og post is about people saying like. "hey dude, i'm not misgendering you" in reference to calling a trans woman "this guy" (real example!). very different problem, though i do appreciate your comment for putting a lot of ideas into words