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Trans Megathread from November 24th, 2025 to November 30th, 2025 (hexbear.net)
submitted 9 months ago* (last edited 9 months ago) by to c/traaaaaaannnnnnnnnns@hexbear.net
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Esther Rose - Wanton Way of Loving

Boulevard Montmartre - Night by Camille Pissarro / La Vie en Rose - Louis Armstrong

Tracey Chapman - Fast Car

Elvis - If I Can Dream

Huangguoshu Waterfall

Pang Xunqin - 1940

Owl on a Pine Branch (1833)

Utagawa Hiroshige

Boston Cremes (1962) - Wayne Thiebaud

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[โ€“] 16 points 9 months ago* (last edited 9 months ago) (8 children)

The doctor confirmed my initial dosage of the cypionate was 1.25mg because apparently it's stronger than the valerate, but that doesn't seem true according to either estrannai.se or https://transfemscience.org/misc/injectable-e2-simulator/? (to be clear I'm on the valerate now, I was only prescribed the cypionate briefly before I saw the low dosage and asked her to switch "because of the expense")

I know I'm beating a dead horse with this but I still almost can't believe it. Is there any good reason for her to say that?

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  • [โ€“] 13 points 9 months ago (1 child)

    It's not stronger, it just has a longer half life than Estradiol Valerate. Both of them are metabolized in your body to the exact same thing - estradiol. In a sense EC is slightly less potent than EV, because 1mg of EV contains 0.76mg of estradiol, while 1mg of EC contains only 0.69mg of estradiol.

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  • [โ€“] 9 points 9 months ago* (2 children)

    It really depends on your levels. How do your levels at trough look? You need to be able to answer that question yourself. Do not rely on a doctor simply telling you your levels are fine. They often lie.

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  • [โ€“] 8 points 9 months ago (1 child)

    Oh I certainly learned that lesson. But I'm talking the overall pharmacokinetics, not how it affects individuals. Plus I haven't actually taken the cypionate so I can't really compare it to the valerate, which I only just started anyway. Taken broadly, it seems like they should be roughly equivalent but differing on frequency?

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  • [โ€“] 8 points 9 months ago

    There's a lot of variation in pharamcogenetics and everyone has a lot of variation in their livers from just good ol genes. Also, depends on othe substances you use or ingest, including some foods and herbs! Pharmacist would probably know way more detail on what the deal is exactly with the two

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