Asklemmy

44144 readers

1145 users here now

A loosely moderated place to ask open-ended questions

Search asklemmy 🔍

If your post meets the following criteria, it's welcome here!

Open-ended question
Not offensive: at this point, we do not have the bandwidth to moderate overtly political discussions. Assume best intent and be excellent to each other.
Not regarding using or support for Lemmy: context, see the list of support communities and tools for finding communities below
Not ad nauseam inducing: please make sure it is a question that would be new to most members
An actual topic of discussion

Looking for support?

Looking for a community?

Lemmyverse: community search
sub.rehab: maps old subreddits to fediverse options, marks official as such
[email protected]: a community for finding communities

~Icon~ ~by~ ~@Double_[email protected]~

founded 5 years ago

MODERATORS

[email protected]

152

How about we play, "Never have I ever"? (fedia.io)

submitted 2 months ago by [email protected] to c/[email protected]

285 comments fedilink hide all child comments

Here's the rules:

1: Post something you have never done that you think many people do. 2: Read the other posts, if you have done that thing, upvote it. If you have not done that thing, downvote it. 3: If you believe the person is lying, call them out on it in a reply. 4: If you are called out, give the full story. 4a: If you see a thread containing the full story, boost the person you think is right and truthful.

Person who has the most upvotes when the thread dies wins.

you are viewing a single comment's thread
view the rest of the comments

[–] [email protected] 2 points 2 months ago* (last edited 2 months ago) (2 children)

where does the tolerance come from though? With alcohol it's very clear that there's one organ doing the heavy lifting. With weed, I have no idea.

To each their own though, not trying to pressure anybody.

Of course! Likewise, I'm not trying to shame anyone for picking weed over beer. Each to their own

Edit: Apparently it's "CB1 receptor density" in your brain that handles the tolerance.

[–] [email protected] 2 points 2 months ago

Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.

[–] [email protected] 2 points 2 months ago

With alcohol it's very clear that there's one organ doing the heavy lifting

It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.