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Is there an over the counter anti-depression or anxiolitic med that you all use? (hexbear.net)

submitted 3 months ago by [email protected] to c/[email protected]

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I hear ashwaganda actually helps? Anyone tried it?

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[–] [email protected] 9 points 3 months ago (1 children)

Some psychiatrists are prescribing buproprion and DXM under separate scripts but in the same dosages as Auvelity to achieve the exact same outcome.

DXM will still work on its own, without bupropion, but it won't be nearly as effective as an antidepressant.

[–] [email protected] 5 points 3 months ago* (last edited 3 months ago) (1 children)

Yeah it's hard to say how effective DXM is on its own, I'm not sure whether there's much research on it if any. But it's worth noting because it's definitely an SNRI. I know some people who don't tolerate Bupropion very well, in those cases it might be worth trying.

[–] [email protected] 1 points 3 months ago* (last edited 3 months ago)

It's only an SNRI in its pro drug form, which is DXM. The reason it is prescribed with Wellbutrin is because it prevents your body from turning DXM into DXO, which is a powerful disassociative.

Additionally the half-life of DXM doesn't make it a very effective SNRI without changing the body's metabolism. The Wellbutrin is the component that changes metabolism.

I've done a lot of personal research with both DXM and it's active metabolite. And have some undergraduate education in pharmacology. I really don't recommend it.