.NET Framework was retired years ago by Microsoft and is in maintenance mode.
.NET (formerly .NET Core) is actively developed and is where Mono was forked into, hence Mono no longer being required. About the only thing Mono might be used for now is running .NET Framework binaries directly on Linux where you might not want the full .NET Framework under wine for compatibility or whatever reason. For example, running TShock (a Terraria server implementation) on Linux.
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