In the movie Point Of No Return, the main character is taught by one of her trainers to say "I never did mind about the little things." To demonstrate the appropriate use of the phrase, later in the movie a guy shoots her friend then looks at her to see how she's going to react and she says it to him. Given the time and perspective thus afforded her, she later kills that guy before he kills her.
I dunno, I just think of that phrase a lot. Also I've been through a lot of big things that make practically everything seem like Little Things in comparison.