If you have a gun that shoots out multiple shots, it's possible to get them both low and then line up a shot with both of them and have them both die on the same turn to different bullets. Kinda involved, but it's the next best option of you dont have good grenades, normality, or really high quickness.

Or you can do my favorite: proselytize one and then kill the other. Congrats, now you have two allies!

normality gas grenades are my go-to, but honestly if they're too troublesome I try to just avoid/ignore them

Level 10 regeneration.

Lose your head? Just grow a new one!

Have you been to the Stilt yet? Lots of merchants there including grenadiers.

I found that the best way to start was to play a few runs as the Marsh Taur preset. They have pretty good survivability, and you can explore the world and try to learn the basics. You'll die a lot, but you'll also learn what kills you. After a few times of doing that (and trying a few different presets), I did a little bit of cheating to revert my save by closing after I died before returning to the menu. I got to about level 25 that way, and I learned a whole lot. I could continue, but I think it's more interesting as a traditional roguelike. Now I'm back to starting new characters when I die, but with a lot more context.

Some people play on RPG mode and that's a perfectly valid way to go too. I believe you revert to the last village you were in if you die.

It's a really deep simulation so it does take a while to learn, but once it clicks you're in for a great time.

I'm totally the same. I feel like I don't know where to go except wander around the first few screens. I've never felt more like a monkey fucking a football. I'm sure this is a fantastic game, but I'm struggling with it. I'll try the advice of the person that replied to you also.