Yeah, I had to change the runner (is that the term? my UI is in French) for half my games after the update. I suspect it just changed it on my existing game configurations for no reason.
I had stuff like proton complaining it can't run 32-bit prefixes, an obscure error saying it couldn't find gamemode... All fixed when I manually changed the runners.
Quite annoying when somzthing that just used ro work suddenly breaks everything.