Least effort solution would be the Neural DSP GOJIRA plugin. It's not cheap but it is excellent. They offer a free trial.
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For 100/150 bucks you get so much in each Archetype suite, I would argue it's actually incredible value. But yes, try them all out for free first!
thanks I'll check it out
That seems like something that would be right up Amplitube's alley.
I used Amplitube in the past and I like it. But what kind of effect chain should I try?
A big muff type of fuzz would be a necessity, IMO. Keep the gain cranked and tone around 9 oclock.
A graphic EQ after to add even more lows and soften the high end wouldnt be a bad idea, either. IIRC, Josh Homme used a parametric EQ to boost the low mids, so if theres a pedal plugin for that, worth a shot as well.
If you have a variety of amps to choose from, something like a model of an Ampeg VT or V4 would be a good bet. Orange, Sunn, and Laney would work well, too.
It depends on your tastes but on my HSS "Strat" I like a Twin Reverb or a Princeton. Then experiment with distortion. For example, I like the strat on position 1 (neck) or 2 (neck + middle) with volume at around 5 and tone at 8 and an HM-2 pulled way back. Levels 6, Distortion 1 or 2, L pulled back and H around middle. Grungy as fuck.
EDIT: Have you tried the presets in Amplitube? Maybe some of the community ones?