It's been funny watching the likes of Stone, Parker, and Jillette slowly come to terms with the reality that most of their enlightened centrist freethinker brosephs were just waiting for a chance to be the boot.

I vote for Tim Minchins "Fuck the Motherfucker" with very minor changes.

In the style of Macho Man, we could go with TACO TACO MAN

The couches were already fucked in Mar-a-lago.

Back in 2016 the final episode was called "The end of serialisation" because the election of Trump (the first time) had fucked all their plans for the season.

much like the current administration and republicans, perhaps the joke is that they "lost the plot"

I think they're in a tight spot. With South Park plots, usually there's a neat bow to tie it all up. And when they do social commentary or political criticism (except for that one bad season), they can just mock whoever it is and go back to normal life at the end. But since the current state of the US is pretty exceptional, and it seems to be in free fall, there is no real way to end political episodes. The people they're mocking can't be portrayed to change, grow, die or become irrelevant, so there's only so much they can do.