Probably not, the Indigenous people in North America were dealing with a three pronged drive from Europe’s major superpowers of the time. Add to that the insane cost of life due to small pox and other diseases and the outlook is much worse.

If they had united, they may have been able to make a stand somewhere further in the west and held on to a portion of the land but I think the fate of the east coast was sealed very early once European migration to America began.