this post was submitted on 23 May 2024
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How are sex hormones synthesized? (hexbear.net)
submitted 5 months ago by [email protected] to c/[email protected]
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I know you can get estrogen from horse urine as a feedstock, but there are other methods used today, right? Do they use other animal products? Petroleum? I'm just looking for a basic overview and don't know where else to look.

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[–] [email protected] 11 points 5 months ago* (last edited 5 months ago) (1 children)

For the purposes of HRT, regardless of application, there are two main estrogens to consider; Estrone (E1) and Estradiol (E2).

Estrone is a weak estrogen in the body it is derived from cholesterol. However, in its most common form of medication, Premarin, it is derived from the urine of pregnant mares. As a weak estrogen that is also not bioidentical (Premarin's chemical structure differs from organic estrone) , it is not as effective as Estradiol in the role of HRT.

Estradiol is the major female sex hormone and as such in it's synthesised ester forms such as Estradiol Valerate it is often considered the most effective form of HRT. It can be derived from diosgenin found in yams, or stigmaserol usually from soybean oil and probably some other plant precursors Im not aware of. It should be noted that most sex hormones can be derived from these methods, stigmaserol for example converts to estrone before it is chemically altered to estradiol.

[–] [email protected] 7 points 5 months ago

Estradiol Valerate it is often considered the most effective form of HRT. It can be derived from diosgenin found in yams,

injecting my legs full of that tuber juice

[–] [email protected] 9 points 5 months ago* (last edited 5 months ago) (1 children)

Near as I can tell, estrogen is synthesized from estrone, and while estrone was originally isolated from the urine, etc. of pregnant women, it is most likely to be synthesized from chemical precursors today, not extracted from urine. Here is a PDF outlining the synthesis (which mentions this is a method broadly used industrially): https://stoltz2.caltech.edu/classes/chem5/7.pdf

I'm not a chemist or anything but I don't see anything there that appears on first search to be an animal product. petroleum may be another story, but not one I feel confident in answering

this article claims it's derived from soy beans: https://www.theguardian.com/business/2022/sep/24/hrt-inside-the-complex-global-supply-chain-behind-a-20bn-market

[–] [email protected] 5 points 5 months ago

Oh very cool, thank you.

[–] [email protected] 6 points 5 months ago* (last edited 5 months ago)

Afaik the funny blue pills are made of yams

There's some guide out there for making it in your bath tub that is uh pretty ill advised

[–] [email protected] 5 points 5 months ago* (last edited 5 months ago) (1 children)

If you're looking for a supplement, DHEA might work. People here probably know more about it, but it's a sex hormone precursor that's available over the counter.

If you want like a complete overview, https://www.ncbi.nlm.nih.gov/books/NBK562873/

[–] [email protected] 3 points 5 months ago

Thanks. Just curious though. I already have prescribed hormones!

[–] [email protected] 4 points 5 months ago (1 children)

You can run an ethical femboy milk farm. This won’t get you any estrogen, but you can do it.

Mostly it’s still horse pee, pig ovaries, and you can do it with yams, as well as cholesterol, although that yields the least result, something like less than 4%

[–] [email protected] 4 points 5 months ago (1 children)

Yams!!

And I imagine the cholesterol also comes from animal sources? Or is it from yeast? 4% sounds low, but then again you gotta grow an entire pig/horse to get it otherwise.

[–] [email protected] 2 points 5 months ago

Karl Djerrasi, who first synthesized oral contraceptives, set up shop in Mexico City because it was close to a good source of wild yams.