That's the xwayland impicit sync stutter. No fix until Nvidia releases 555 drivers with explicit sync compatibility (beta on may 15) and no vulkan fix until 560 drivers.
In my experience most games don't exhibit it, although the number that do has increased in recent driver versions where Nvidia tried workarounds for implicit sync. You could try downgrading to 545 and see if it has the issue.
Edit: just saw you said you used the Wayland build of wine. I guess that also has the same issue