Oh for sure! It's really just treating D&D as the default that I have a problem with, not using an existing system per se. Sometimes it works, but a lot of the time making D&D support a radically different style of play is a bad idea. It also tends to suggest that either the designer doesn't really know that much about RPGs, or the publisher doesn't care and just wants to cash in on what's popular. If they picked even another existing system, that at least suggests they're aware of other games, and probably picked something they thought was a good fit.

Again, this is just speaking in generalities. There are good games based on 5e. It's a red flag, but not a deal breaker.