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Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)

submitted 1 year ago by [email protected] to c/[email protected]

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A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

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[–] [email protected] 2 points 1 year ago

This is not true. The laws of thermodynamics apply to open systems as well as long as you take into account the energy that enters and leaves the system, which is exactly what calories in, calories out mean. The brain influencing how many calories are spent is just part of calories out. What doesn't work is equating calories out with imprecise estimates from websites, watches etc, or equating calories in with imprecise calorie counts from food labels that people often miscount anyway. But when calories are carefully measured by scientists (i.e. in a metabolic chamber) and everything is accounted for, it's calories in, calories out all the way.