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Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)

submitted 1 year ago by [email protected] to c/[email protected]

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A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

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[–] [email protected] 4 points 1 year ago

Believe it or not, what you swallow has almost nothing to do with your weight. The only place the body absorbs energy from food is in the intestines, and the brain controls that process.

I would believe it if I started gaining weight by just breathing. Also, no. Not the only place. Part of the alcohol consumed is absorbed through the stomach.

The digestive tract is a tube, open at both ends, through which food passes. The process of extracting energy from that food is complex and highly tunable: the brain controls the production and secretion of hundreds of enzymes and other chemicals, as well as the physical action of the muscles lining the tube.

The brain controls pretty much everything, and this everything is highly tunable. I mean, how else would well adjusted people adapt to the highly complex lives they live as adults? With commercial pills?