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[–] 51 points 6 months ago (8 children)

Aren't ssris like almost placebo levels of effectiveness? Almost like nothing cures depression

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  • [–] 18 points 6 months ago (5 children)

    it's like 1/3 no effect, 1/3 does something but side effects are intolerable, and 1/3 helpful and tolerable

    seems unreasonable to me that we make attempts that have less than a 50% chance of expected success

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  • [–] 1 point 6 months ago (4 children)

    Why? You can just stop taking it if it doesn't help, so a small chance at an easy improvement makes sense

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  • [–] 7 points 6 months ago (3 children)

    because of the other third of the time where it makes your life worse?

    we also are cautious about prescribing them to teens because your motivation comes back before the mood stabilization and that increases follow-through on ideation.

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  • [–] 1 point 6 months ago (2 children)

    If it makes you feel worse, you can stop taking it

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  • [–] 8 points 6 months ago (1 child)

    worse is way worse, you have to taper which is more misery, and kids kill themselves. for a 30% chance at improvement.

    i don't understand how to make it more clear that those odds are garbage and that the bet makes no sense.

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  • [–] 1 point 6 months ago*

    I've tapered off of several drugs including SSRIs (which, best as I can tell, did nothing but make my brain feel physically bad). It's not a big deal and it's not like it curses you for life.

    The suicide point is completely frivolous because those are broadly cases of people who were too depressed to even try killing themselves becoming less depressed. It's statistically just part of recovering from severe depression that you need to pass through a "band" or stratum or whatever where your propensity for suicide is higher because you need to get a sense of motivation and agency back and getting that back in the context of having just spent all your time imagining killing yourself can result in choosing to act on those imaginings. It's not a problem unique to SSRIs, it's just observable with antidepressants because they are one of relatively few things that can be easily administered and help depression in a significant portion of the recipients.

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  • [–] 9 points 6 months ago

    Like all psychoactive substances, it varies from person to person. I have been on SSRIs at one point and I just dropped them after months of mostly experiencing just annoying side effects. A friend of mine is okay with them and told me they genuinely help her be functional.

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