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Don’t panic, but an asteroid has a 1.9% chance of hitting Earth in 2032
(arstechnica.com)
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Right now.
Forever, humanity could only ever conceivably expand so far due to the expansion of the universe, so as far as we know a still insignificant portion of the universe we could colonize.
Until we make some scientific breakthrough which might solve that problem. If there is any possible of course. There is so much we still don't know.