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‘Unprecedented risk’ to life on Earth: Scientists call for halt on ‘mirror life’ microbe research
(www.theguardian.com)
this post was submitted on 13 Dec 2024
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So the biomass of the mirror organisms will not increase in nature?
Yes, it cannot be created naturally.
The concern is that if one of the mirror proteins is able to be cloned naturally, then we would have a problem on our hands.
However, those mirror cells would need a supply of "mirror food" such as "mirror sugar" in order to survive their natural lifespan. And then they would need to break apart into the mirror proteins that can be cloned. Racemic drugs like Thalidomide do not behave the way they are talking about in the article.
I have my doubts that this is an actual concern. It's not even similar to prions - prions are misfolded proteins that have the same chemical make up, but the natural enzymes end up cloning those over the natural ones because they are easier to make.
"mirror sugar". Just dropping some trivia. The first "no calorie" sweetners were actually mirror sugar. They'd activate tastebuds but couldn't be adsorbed in the gut. Only problem was people crapped their brains out because the osmotic balance went to hell.
edit: I think technically the first zero calorie sugar would have been literal lead (as in Pb) back in the ancient roman days, but I'm not really counting that.
See I didn't know that, cool thanks
you bet! I just remember that because we were learning about glucose is taken up (it's an active process swapping sodium and potassium). Another fun bonus for you: thats what they figured out at university of florida (or at least implemented). Someone had the bright idea that if you gave athletes a beverage with not only glucose but the specific K+/Na+ they needed to run the enzymes that took up the glucose, they might perform better.
So the football team, the Gators, got a special concoction of "Gator-aide" at their games. It smelled kinda like sweat, wasn't sweet (glucose isn't actually that sweet), so the formula was eventually tweaked, the branding changed to "gatorade", but the university still RAKES in the money for that license.
edit: Just to add another cool layer. The money to date has nothing to do with the innovation, that patent would have expired (which is fantastic because that concoction is basically how you treat all sorts of things like cholera where the body dies of dehydration despite having clean water, the UN, FEMA, etc basically hands out off-brand gatorade mix). The reason U of florida still gets the money isn't formula, it's the brand. Pepsi pays them for that "gator-aide" name. It's rare IP perfect win; hydration mix for all, and if you there's a business to be made selling it under a specific name so be it, doesn't matter much to the person whos life is saved because of "generic hydration mix".
Jumping in down here. I agree with you entirely that racemic mixes are a very different ball than mirror organisms; it's been a known thing for a long time, and while I'm not positive, I'd be very surprised if FDA testing didn't include different chiralities of both the original compound and metabolite.
That being said, there's nothing to say one version of a chiral protein can't behave like a prion. I don't know of any evidence where we've seen it happen either, though. There's also potentially the issue of partial bonding. Not every domain on every protein is chiral. If a mirror protein has some domains that bind but other functional domains that are incompatible, you could see it incorporated into complex that either 1) are now non-functional or 2) have alternate folding that behaves similar to prions.
Again though, I can't point to any evidence of that. You can do the arrow pushing that shows how you get tetrodoxin from the stuff in your tea or coffee, it doesn't mean it's actually going to happen beyond the statistical realm interesting only to quantum physicists.
Just chiming in because your comments are level headed and you've clearly got some knowledge in the area and appreciate the discussion. Looking forward to digging into the report this weekend, I had no idea this was even something are even attempting!
Agreed. And while deadly, prions don't spread except through living organisms. It's not like they're converting all the proteins in the world without check.
Depends if the mirror organisms in question can photosynthesize
ooooh this is it! If you wanted to optimize evil add photosynthesis and nitrogen fixing and you've got it.
Hell, I'd bet you could work on the chloroplasts in isolation of the rest of the organism to parallel path the research and optimize.