This is surrendering before the fight has even begun. And that surrendering is why centrist democrats lose. Those powerful interests can bitch all they want. Will it cost you donors? Sure. But Kamala and Hillary both massively outraised Trump, and look at what good it did them.
What centrist muppets fail to recognize is that fundraising isn't everything, especially on national races. Or more precisely, there is such a thing as marketing saturation. At some point, you've convinced everyone that can be convinced, reached everyone that can be reached. And the level of fundraising necessary to achieve that saturation is a level that can be achieved with small dollar individual donations.
Trump ran on, and won on, a promise to deport 20 million people. You think the businesses that profit from illegal immigration might put up some resistance to that? Take a look at Trump's platform
Seal the border and stop the migrant invasion
That would doubtlessly anger the industries that depend on migrant labor.
Carry out the largest deportation operation in american history
See above.
End inflation, and make america affordable again
That would require price controls or anti-monopoly actions, which big retailers would oppose.
Make america the dominant energy producer in the world, by far!
The electric car and renewable power companies aren't going to like that at all.
Stop outsourcing, and turn the united states into a manufacturing superpower
Those jobs were outsourced in order to make high profits; the companies doing the outsourcing will oppose this.
large tax cuts for workers, and no tax on tips!
Why give dollars to workers, when you could give them to wealthy and powerful interests? This is going to make some wealthy people mad.
I could go on. Trump ran on the message of a populist, and he won. He ran on things that would anger a large number of very wealthy people and corporations if implemented. His number one issue, illegal immigration? Aside from a the Border Patrol union, what powerful interest will actually benefit from mass deportation? Maybe the private prison companies will make some cash, but there are far more wealthy donors who benefit from illegal immigration than would benefit by mass deportation.
Trump promised all sorts of things. He promised things that his base wanted and that many corporations oppose. They're things that I find abominable, but it's what his base wants. And that is ultimately why he won.