Wheeled carts are not very practical without draught animals to pull them. And the one place they had animals like that, in South America, llamas and the civilizations that utilized them lived in the mountains where wheeled carts aren't practical either.

Most American natives devolped their societies without much need for the wheel in a similar way that most European's societies devoloped without much need for kayaks or river travel.

One possible reason for this is the lack of useful draft animals. Even with a cart a person can't move much more than they can carry, especially across rough terrain. You'll note that the wheel wasn't developed in the west until after the domestication of oxen and horses, and since they had both died out in the Americas there wasn't anything strong enough to pull the carts.

For carrying large amounts of cargo native Americans would use a travois, which could be dragged behind a person or dog or, eventually, a horse.