this post was submitted on 16 Oct 2024
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Science Memes

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Hmmmm (mander.xyz)
submitted 1 month ago by [email protected] to c/[email protected]
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[–] [email protected] 17 points 1 month ago (4 children)

I'm currently writing a small literature review on tgf-b and SMAD signalling in cancer for uni rn

And I'm really confused why this one paper's talking about how miR-520h induces the tgf-b/smad7 pathway but also binds to and suppresses smad7

Like why on earth is it activating the tgf-b/smad7 pathway, a pathway that stops stuff like the epithelial mesenchynal transition, if it's just going to bind to smad7 anyway???

Worst thing is, I can't find any other papers on why this actually happens

I swear I'm just dumb at times ;-;

[–] [email protected] 17 points 1 month ago (1 children)

[–] [email protected] 1 points 1 month ago

I'll take two scoops

[–] [email protected] 8 points 1 month ago

Ah, yes. Of course. I understand your frustration entirely because of my deep understanding of the specific situation.

[–] [email protected] 5 points 1 month ago (1 children)

Would a list of tools and search engines be helpful?

[–] [email protected] 1 points 1 month ago (1 children)

That would be very helpful 🥴

[–] [email protected] 2 points 2 weeks ago

Sorry, better late than never. Will dm you. Others are welcome too.

[–] [email protected] 4 points 1 month ago

Cell signalling pathways was the worst part of microbial genetics for me. Luckily I don't have to deal with that anymore as my day to day is digital PCR and NGS.