Sites like Hexbear source scripts from only one domain (hexbear.net). I like those sites.
Other sites loop in a few JavaScript libraries. They have a few domains asking for permissions. That's okay. A little lazy, but acceptable.
Then you have the corporate websites with, like, sixty JavaScript domains. Holy crap! What are scripts from facebook, pinterest, and amazon doing on this news article about jellyfish? 
And the website is perfectly functional with just a couple domains enabled. 
I thought Umatrix was unmaintained?
Anyway, I used to use it till a few years ago. It's a really powerful extension, but it breaks some sites with the default settings and it can get tedious reenabling scripts one by one to find the bare working minimum. I have since switched to uBlock of the same developer and it seems to me an adequate compromise between privacy, better performance and working sites.
Unfortunately the modern web has turned into tihs so you can't even browse without an ad blocker anymore.
That's fair. I've used noscript for 4 years and the default is awful. I looked a bit into using uBlock for blocking scripts but I just noped out.