this post was submitted on 26 Jul 2023
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Unless it’s a single-gene mutation, won’t be super predictive
Ooh that's got me curious - for this case when both parental lines have history, does that not matter in assessing likelihood or just not at all?
dementia can be caused by single gene (simple inheritance), or multiple gene variants, or by interactions between those variants with your lifestyle and environment (complex inheritance). If it’s the simple type, and your parents both have the same mutation, you definitely would get it. Complex is less straightforward- you likely did inherit at least 1 copy, but it won’t necessarily mean you will for sure get it. In fact you may not even develop it. It does increase the risk though, and some say healthy diet and healthy lifestyle can reduce this risk to zero.
I see, thank you!