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Abstract

Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends from gestation into adulthood. However, few environmental chemicals have been assessed for potential risks to oligodendrocytes. Here, using a high-throughput developmental screen in cultured cells, we identified environmental chemicals in two classes that disrupt oligodendrocyte development through distinct mechanisms. Quaternary compounds, ubiquitous in disinfecting agents and personal care products, were potently and selectively cytotoxic to developing oligodendrocytes, whereas organophosphate flame ret#rdants, commonly found in household items such as furniture and electronics, prematurely arrested oligodendrocyte maturation. Chemicals from each class impaired oligodendrocyte development postnatally in mice and in a human 3D organoid model of prenatal cortical development. Analysis of epidemiological data showed that adverse neurodevelopmental outcomes were associated with childhood exposure to the top organophosphate flame ret#rdant identified by our screen. This work identifies toxicological vulnerabilities for oligodendrocyte development and highlights the need for deeper scrutiny of these compounds’ impacts on human health.

Abstract

The Earth’s energy imbalance is the net radiative flux at the top-of-atmosphere. Climate model simulations suggest that the observed positive imbalance trend in the previous two decades is inconsistent with internal variability alone and caused by anthropogenic forcing and the resulting climate system response. Here, we investigate anthropogenic contributions to the imbalance trend using climate models forced with observed sea-surface temperatures. We find that the effective radiative forcing due to anthropogenic aerosol emission reductions has led to a 0.2 ± 0.1 W m−2 decade−1 strengthening of the 2001–2019 imbalance trend. The multi-model ensemble reproduces the observed imbalance trend of 0.47 ± 0.17 W m−2 decade−1 but with 10-40% underestimation. With most future scenarios showing further rapid reductions of aerosol emissions due to air quality legislation, such emission reductions may continue to strengthen Earth’s energy imbalance, on top of the greenhouse gas contribution. Consequently, we may expect an accelerated surface temperature warming in this decade.

500,000 to 1 million satellites are expected in the next decades, primarily to build internet constellations called megaconstellations. These megaconstellations are disposable and will constantly re-enter and be replaced, hence creating a layer of conductive particulate. Here it will be shown that the mass of the conductive particles left behind from worldwide distribution of re-entry satellites is already billions of times greater than the mass of the Van Allen Belts. From a preliminary analysis, the Debye length in spaceflight regions is significantly higher than non-spaceflight regions according to CCMC ionosphere data. As the megaconstellations grow, the Debye length of the satellite particulate may exceed that of the cislunar environment and create a conductive layer around the earth worldwide. Thus, satellite reentries may create a global band of plasma dust with a charge higher than the rest of the magnetosphere. Therefore, perturbation of the magnetosphere from conductive satellites and their plasma dust layer should be expected and should be a field of intensive research. Human activity is not only impacting the atmosphere, it is clearly impacting the ionosphere.

Abstract

Perfluoroalkyl acids (PFAAs) are highly persistent anthropogenic pollutants that have been detected in the global oceans. Our previous laboratory studies demonstrated that PFAAs in seawater are remobilized to the air in sea spray aerosols (SSAs). Here, we conducted field experiments along a north-south transect of the Atlantic Ocean to study the enrichment of PFAAs in SSA. We show that in some cases PFAAs were enriched >100,000 times in the SSA relative to seawater concentrations. On the basis of the results of the field experiments, we estimate that the secondary emission of certain PFAAs from the global oceans via SSA emission is comparable to or greater than estimates for the other known global sources of PFAAs to the atmosphere from manufacturing emissions and precursor degradation.

Abstract Here, we show that the Last Glacial Maximum (LGM) provides a stronger constraint on equilibrium climate sensitivity (ECS), the global warming from increasing greenhouse gases, after accounting for temperature patterns. Feedbacks governing ECS depend on spatial patterns of surface temperature (“pattern effects”); hence, using the LGM to constrain future warming requires quantifying how temperature patterns produce different feedbacks during LGM cooling versus modern-day warming. Combining data assimilation reconstructions with atmospheric models, we show that the climate is more sensitive to LGM forcing because ice sheets amplify extratropical cooling where feedbacks are destabilizing. Accounting for LGM pattern effects yields a median modern-day ECS of 2.4°C, 66% range 1.7° to 3.5°C (1.4° to 5.0°C, 5 to 95%), from LGM evidence alone. Combining the LGM with other lines of evidence, the best estimate becomes 2.9°C, 66% range 2.4° to 3.5°C (2.1° to 4.1°C, 5 to 95%), substantially narrowing uncertainty compared to recent assessments.