Haven't played em, but Eat the Reich looked interesting. Vampires killing nazis. I remember reading something a while back called World of Future Darkness, which mixed Cyberpunk and Vampire the masquerade, however I'm not sure if that was ever expanded upon or which system it used.
I was working on a module for Savage Worlds that was basically World of Future Darkness with simplified lore and adapted to SWADE, but I never ended up running it to test it since I'm pretty sure the supernatural ancestries and cybernetics will need some work. If you're interested DM me and I'll give you the pdf.
I don't hate 5e, in fact I'd join in as a player very happily, but I wouldn't run it. 5e is geared towards a very specific kind of campaign that I'm not very interested in running.
I'm more of a social campaign with big action sequences kind of DM and Savage Worlds does that perfectly. It is:
I tried to turn 5e into something that fit a cyberpunk setting for about 3 months, before just buying SWADE and being able to run every genre I could imagine from the go.