this post was submitted on 07 Feb 2024
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Research by UCL, which examined medical records of 260,000 men with erectile dysfunction, has provided ‘food for thought’

After a decades-long and largely fruitless hunt for drugs to combat Alzheimer’s disease, an unlikely candidate has raised its head: the erectile dysfunction pill Viagra.

Researchers found that men who were prescribed Viagra and similar medications were 18% less likely to develop the most common form of dementia years later than those who went without the drugs.

The effect was strongest in men with the most prescriptions, with scientists finding a 44% lower risk of Alzheimer’s in those who received 21 to 50 prescriptions of the erectile dysfunction pills over the course of their study.

While the findings are striking, the observational study cannot determine whether Viagra and similar pills protect against Alzheimer’s or whether men who are already less prone to the condition are simply more likely to use the tablets.

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[–] [email protected] 20 points 10 months ago

"an unlikely candidate has raised its head", really ?!?

[–] [email protected] 13 points 10 months ago (1 children)

Better blood flow... I can see that helping things. Wasn't Viagra originally being researched for blood pressure?

[–] [email protected] 4 points 10 months ago (1 children)

Could also be they have more to live for

[–] [email protected] 8 points 10 months ago (1 children)

Could also be men with Alzheimer's are less likely to be seeking Viagra.

[–] [email protected] 1 points 10 months ago

It just helps old dudes remember the last time they got laid.

[–] [email protected] 6 points 10 months ago

I know that recent scholarship correlated sleep quality with resistance to dementia onset. Call me crazy but having good sex is the surest precursor to a good nights sleep.

[–] [email protected] 6 points 10 months ago

"Where the hell am I, and how come I have a raging hard on?"

[–] [email protected] 4 points 10 months ago (2 children)
[–] [email protected] 3 points 10 months ago (1 children)

Made me lol, but honestly didn't even have to change the quote.

[–] [email protected] 2 points 10 months ago (1 children)
[–] [email protected] 2 points 10 months ago (1 children)

But, on the other hand...boners.

[–] [email protected] 1 points 10 months ago (1 children)
[–] [email protected] 1 points 10 months ago

"Aye we've already had first dick, but what about second dick?"

[–] [email protected] 3 points 10 months ago

I know the blood flow seems obvious, but lesser known is the fact that phosphodiesterase inhibitors have direct impacts on the nervous system. There's a PDE4 inhibitor that is commonly used in Japan to treat post-stroke inflammation. (Also, caffeine is a weaker, broad spectrum PDE inhibitor.)

"Firstly, PDE5 inhibitors could enhance memory and learning by increasing long-term potentiation mediated by the glutamate NO-cGMP intracellular pathway, as cGMP-activated protein kinase is thought to mediate memory consolidation.

Secondly, as cGMP is a known vasodilator, the cognitive effects of PDE inhibition could be explained by enhanced cerebrovascular function owing to increased delivery of glucose and oxygen to the brain. Finally, improved erections might alleviate performance anxiety and boost self-confidence, with potential benefits to mood, cognition, and general health."

https://www.nature.com/articles/nrurol.2013.309

[–] [email protected] 2 points 10 months ago

A boner you'll never forget.

[–] [email protected] 2 points 10 months ago

I've read just yesterday Wikipedia's page on Oxytocin, and it states that it delayed symptoms of Alzheimer's disease. Oxytocin is released during and/or after sex. This could be simply that people with Viagra prescriptions are more likely having more sex, and so more Oxytocin being released by the brain, and delaying Alzheimer's.

[–] [email protected] 1 points 10 months ago