Not sure what sort of isolation you're expecting but yes, QEMU + virt-manager will be a very similar experience to using virtualbox. Both offer the same sort of isolation so I don't think you'd run into any surprises.
In both managers the VM does usually have internet access by default via NAT switch on the host system but you could re-configure it to bridge networking if you wanted. You could probably get rid of the NIC entirely if you don't want it to have network access (haven't personally needed to do that but it should be doable).
You do need to do some extra configuration if you need to share files between the Linux host and the Windows VM but I suspect you don't want to do that if you're looking for isolation.