No.

If you’ve skipped the first 3 you won’t miss anything by skipping 4. Except the Denuvo, you’ll miss that because 4 has it right now.

Only if you own a SSD

(I actually liked borderlands 2)

instead of playing borderlands you could just get a lobotomy for the same experience

Great question! No, Borderlands 4 is a great first Borderlands game to skip. Happy (non-)gaming!

You can understand the game's story and appeal by playing any of the games for 5 to 10 minutes, skip the others in any order you like after that.

True lore masters do something similar, but they also add the games to their steam library and then skip them for other games in order of release afterwards (for example, most gamers are deepening their lore knowledge by skipping this installment after downloading it and playing silksong instead).

Is Borderlands 4 out or something?

Why isn't it called 4derlands?