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[–] 110 points 1 year ago (4 children)

They found the cure for Sigma

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  • [–] [S] 52 points 1 year ago (2 children)
  • [–] 46 points 1 year ago (3 children)

    Why don't they just prescribe this instead of stuff that doesn't help and also breaks your penis? 😬

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  • [–] 85 points 1 year ago (3 children)

    Dopamine does a lot of things. It does not cross the blood-brain barrier.

    So taking this would be all side effects and no benefits

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  • [–] 44 points 1 year ago (1 child)

    Just inject it straight into your brain

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  • [–] 25 points 1 year ago (2 children)

    So taking this would be all side effects and no benefits

    So it's basically the same as Prozac? 😩

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  • [–] 33 points 1 year ago (4 children)

    If you have depression anxiety and find that Prozac (an ssri) doesnt work well, you might consider something that directly works on dopamine - like Buproprion (brand name = wellbutrin, a NDRI, norepinephrine dopamine reuptake inhibitor).

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  • [–] 7 points 1 year ago (1 child)

    SNRIs are also an option, but they can be worse to get off of than heroin.

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  • [–] 4 points 1 year ago

    I was on Effexor XR Max Dose, and one day when I realized that it had effectively killed all feelings I stopped cold turkey, zero side effects. My doctor thinks I have a very high drug tolerance, to the point that anything I'm put on nowadays is just started at close to the max dose. I'm on a drug right now that is prescribed at a level that would normally result in death for most people, and he thinks I can go higher if I need to.

    Downside is pain drugs don't work, at all. He told me they'd need to give me IV pain meds if I really needed any pain suppression.

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  • [–] 4 points 1 year ago (3 children)

    This is obviously anecdotal, but fuck Wellbutrin. It didn't help, and it triggered tinnitus, which didn't go away after I stopped taking it. Still happening 2 years later. I'm one of the lucky 3-6% Eeeeeeeeeeeeeeeeeeee

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  • [–] 11 points 1 year ago* (1 child)

    I realize this isn't serious but holy shit Prozac might have saved my life. Well, technically Prizma which is the same stuff. I went through so many unsuccessful depression treatments, Prizma is the only one that seems to be sticking. Sometimes the old stuff is just the best.

    Worth noting that all treatments were in conjunction with psychotherapy, I don't think pills alone would have helped. And I also tried going without medication at all for a while, it wasn't good either. Prizma really is the only thing that works for me.

    Edit: apparently the Prizma brand might only be sold in my country, but as I said it's just a different brand of Prozac.

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  • [–] 14 points 1 year ago (1 child)

    I might be misremembering, but AFAIK, dopamine can't cross the blood-brain-barrier, so even where you want to regulate dopamine (and not, e.g. serotonin like more commonly for depression) in the brain, you have to do so via different medication (e.g. amphetamine derivatives for ADHD or dopamine agonists for Parkinson's).

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  • [–] 7 points 1 year ago

    From Wikipedia on dopamine:

    The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior.

    So it is a neurotransmitter but has many different functions as such. But also:

    Outside the central nervous system, dopamine functions primarily as a local paracrine messenger. In blood vessels, it inhibits norepinephrine release and acts as a vasodilator; in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it.

    So dopamine is important for all kinds of cells to function correctly. So just chugging a bunch of dopamine would do all kinds of stuff to your body...

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  • [–] 37 points 1 year ago (1 child)

    As a non-chemistry person, I assume the red diamonds are to ensure I don't put this in my mouth?

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  • [–] 13 points 1 year ago (6 children)

    The first is a standard warning symbol, telling you to read the warnings.

    The middle looks to imply that it's harmful to aquatic life; so no flushing, (upside-down fish and a piece of coral)

    Third one seems to be dosage frequency, but saying a symbol isn't available. (QHS = taken every night)

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  • [–] 14 points 1 year ago (1 child)
  • [–] 10 points 1 year ago (1 child)
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    [–] 9 points 1 year ago (1 child)

    Shove it right up my eyeballs!

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  • [–] 6 points 1 year ago
    [–] 6 points 1 year ago* (1 child)

    I have no idea what that middle warning symbol is trying to convey. Raises undead fish from their graves? Makes you throw fish at your neighbor's driveway? Will cause flooding across the entire state of Virginia?

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