Risk factors play a pivotal role in shaping the AL burden spectrum. The research distinctly identifies high body mass index (BMI), tobacco smoking, and exposures to occupational carcinogens such as benzene and formaldehyde as principal contributors to DALYs attributable to acute leukemia. Notably, high BMI and smoking prevalently drive leukemia risks in developed nations, while occupational exposures remain more critical in developing economies. This dichotomy reflects disparate environmental and lifestyle contexts, underscoring the necessity for targeted intervention frameworks spanning prevention, regulation, and behavioral health.