I think the pope was just talking about setting up some guidelines on genAI so funny time to ask this question.
I think if there was artificial life that was fully sapient, had qualia, and showed the capacity to make meaningful decisions through reason there's not really much reason to doubt that it has a soul. Maybe those criteria are not useful because you can't prove that someone else has qualia, but at least philosophically. Now, the problem is, what if it doesn't have a physical body? I think I'd be too conflicted on that to really come to any definite view. I'd probably wait on the pope to say something lol
edit: also just to be clear, if it has a soul then it can be baptized and should be treated the way we treat humans in general. I don't know if Francis was the first pope to ever say anything on the question of how we should react to alien life, but he definitely said that much. I don't think artificial life would really be too different except for the fact it wouldn't be God's creation. As you said, the question of whether or not we should make artificial life is outside the scope of the thread.