this post was submitted on 21 Jan 2025
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Science

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Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

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[–] [email protected] 61 points 1 month ago (1 children)

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

[–] [email protected] 7 points 1 month ago (1 children)

Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn't know?

[–] [email protected] 7 points 1 month ago (1 children)

ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth

[–] [email protected] 3 points 1 month ago

Like a lil cashew down there.

[–] [email protected] 42 points 1 month ago (1 children)

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

[–] [email protected] 7 points 1 month ago (2 children)
[–] [email protected] 28 points 1 month ago

The hat man cleans your brain for you.

[–] [email protected] 8 points 1 month ago

Unknown, but it's an anticholinergic, and those are associated with dementia.

[–] [email protected] 27 points 1 month ago (2 children)

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I'll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I'm allowed to be a real human. Guess my brain will clean itself when I die.

[–] [email protected] 9 points 1 month ago

Be careful about assuming that your drugs are what they're talking about. Yours sound like they're balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.

[–] [email protected] -2 points 1 month ago

you probably just need fresh nutrients

[–] [email protected] 15 points 1 month ago (1 children)

I wonder if ketamine has the same effect, he asked apropos of nothing...

[–] [email protected] 12 points 1 month ago (1 children)
[–] [email protected] 12 points 1 month ago

Actually maybe not? Iirc most "traditional" anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a "blink and you miss it" ordeal, your brain isn't active enough to be aware that time has passed).

However, if I'm not mistaken, stuff like ketamine or nitrous don't do that, and sedate you in a manner more similar to natural sleep.

[–] [email protected] 11 points 1 month ago (3 children)
[–] [email protected] 6 points 1 month ago (1 children)
[–] [email protected] 2 points 1 month ago (1 children)

Then gets you really sleepy

[–] [email protected] -1 points 1 month ago

Being knocked out is not sleep.

[–] [email protected] 3 points 1 month ago

Suppresses dreams and dreams are apparently good and needed for a healthy brain.

[–] [email protected] 0 points 1 month ago (1 children)

Se thing as any other substance

Weed too

[–] [email protected] 1 points 1 month ago (1 children)
[–] [email protected] 0 points 1 month ago

That shit don't last long enough?

[–] [email protected] 9 points 1 month ago (1 children)

Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.

Good to see this common sense being confirmed

[–] [email protected] 1 points 1 month ago

I wouldn't even call it common sense. I remember being taught like 20 years ago that we don't even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).

[–] [email protected] 7 points 1 month ago (2 children)
[–] [email protected] 7 points 1 month ago

That usually helps me sleep better too

[–] [email protected] 0 points 1 month ago
[–] [email protected] 6 points 1 month ago

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

[–] [email protected] 5 points 1 month ago (2 children)

I wonder what melatonin does

[–] [email protected] 5 points 1 month ago (2 children)

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

[–] [email protected] 9 points 1 month ago

Probably just stick to the side of your head.

Have you tried eating the cheese instead?

[–] [email protected] 4 points 1 month ago (1 children)

Charlie Kelly... who taught you about Lemmy?

[–] [email protected] 2 points 1 month ago

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain...

[–] [email protected] 5 points 1 month ago (1 children)

It's a natural hormone brain produces that signals to the body that it's zzz time.

[–] [email protected] 2 points 1 month ago (1 children)

I love it for bedtime and it helps my autoimmune shit. Glad it's not brain bad.

[–] [email protected] 2 points 1 month ago

Aside from possibly becoming a dependency, I'd imagine it doesn't interfere with sleep quality. It's what builds up in your body to make you sleepy/fall asleep.

Too much might keep you groggy in the morning though.

[–] [email protected] 5 points 1 month ago

If you want your brain to clean out waste at night, you need to be taking sweeping pills.

[–] [email protected] 4 points 1 month ago* (last edited 1 month ago)

You need healthy, natural sleep. Chew some valerian root and get more exercise.

[–] [email protected] 2 points 1 month ago (1 children)

Apparently the water supply in my town is dosed with sleeping pills.

[–] [email protected] 9 points 1 month ago

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater