Best is a matter of how you rank features! The FT-60R suggestion is a good one, but that's a choice of robustness (it's incredibly solid) over some other features. If you're after satellite work, it's not a great choice. Or if you're really interested in APRS tracking during your runs, it's also not a great choice. Or, like in my situation, I need to help my local club in working with their Yeasu 70cm repeater running FM and C4FM, which is why I have a FT-70DR.
The UV-5R is doing you well. Let's find things you'd like to do that it doesn't do well. Is it 1.25m band support? FM satellites? Audio quality? Digital modes? The radio's physical size or hand feel?
Or are you beginning to think about beyond HT, but still portable. Like HF or trying out SSB on VHF?